In:
Journal of Medical Virology, Wiley, Vol. 95, No. 2 ( 2023-02)
Abstract:
Avian influenza virus, which frequently jumps to humans and causes severe illness and death, poses a continuing threat to public health. Understanding the genesis and characteristics of avian influenza viruses will help prevent future human influenza pandemics. In this study, we provide evidence that the human‐infecing H10N3 viruses are reassortants with internal genes from chicken H9N2 viruses and surface genes from duck viruses, suggesting a critical role for ducks in the generation of viruses with human‐infecting potential. Our findings demonstrate that some H10N3 viruses exhibit higher affinity for human‐type receptors than for avian‐type receptors, and some can transmit via direct contact and/or respiratory droplets in the guinea pig model, suggesting the potential risk posed by H10N3 viruses.
Type of Medium:
Online Resource
ISSN:
0146-6615
,
1096-9071
Language:
English
Publisher:
Wiley
Publication Date:
2023
detail.hit.zdb_id:
752392-0
detail.hit.zdb_id:
1475090-9