In:
Journal of Magnetic Resonance Imaging, Wiley, Vol. 58, No. 3 ( 2023-09), p. 951-962
Abstract:
Diffusion‐weighted imaging (DWI) may allow for breast cancer screening MRI without a contrast injection. Multishot methods improve prone DWI of the breasts but face different challenges in the supine position. Purpose To establish a multishot DWI (msDWI) protocol for supine breast MRI and to evaluate the performance of supine vs. prone msDWI. Study Type Prospective. Population Protocol optimization: 10 healthy women (ages 22–56), supine vs. prone: 24 healthy women (ages 22–62) and five women (ages 29–61) with breast tumors. Field Strength/Sequence 3‐T, protocol optimization msDWI: free‐breathing (FB) 2‐shots, FB 4‐shots, respiratory‐triggered (RT) 2‐shots, RT 4‐shots, supine vs. prone: RT 4‐shot msDWI, T2‐weighted fast‐spin echo. Assessment Protocol optimization and supine vs. prone: three observers performed an image quality assessment of sharpness, aliasing, distortion (vs. T2), perceived SNR, and overall image quality (scale of 1–5). Apparent diffusion coefficients (ADCs) in fibroglandular tissue (FGT) and breast tumors were measured. Statistical Tests Effect of study variables on dichotomized ratings (4/5 vs. 1/2/3) and FGT ADCs were assessed with mixed‐effects logistic regression. Interobserver agreement utilized Gwet's agreement coefficient (AC). Lesion ADCs were assessed by Bland–Altman analysis and concordance correlation ( ρ c ). P value 〈 0.05 was considered statistically significant. Results Protocol optimization: 4‐shots significantly improved sharpness and distortion; RT significantly improved sharpness, aliasing, perceived SNR, and overall image quality. FGT ADCs were not significantly different between shots ( P = 0.812), FB vs. RT ( P = 0.591), or side ( P = 0.574). Supine vs. prone: supine images were rated significantly higher for sharpness, aliasing, and overall image quality. FGT ADCs were significantly higher supine; lesion ADCs were highly correlated ( ρ c = 0.92). Data Conclusion Based on image quality, supine msDWI outperformed prone msDWI. Lesion ADCs were highly correlated between the two positions, while FGT ADCs were higher in the supine position. Evidence Level 2. Technical Efficacy Stage 1.
Type of Medium:
Online Resource
ISSN:
1053-1807
,
1522-2586
Language:
English
Publisher:
Wiley
Publication Date:
2023
detail.hit.zdb_id:
1497154-9
