In:
Journal of Hepato-Biliary-Pancreatic Sciences, Wiley, Vol. 21, No. 11 ( 2014-11), p. 809-817
Kurzfassung:
Cholangiocarcinoma has been reported in workers exposed to chlorinated organic solvents and has consequently been classified as an occupational disease (occupational cholangiocarcinoma) by the J apanese M inistry of H ealth, L abour and W elfare. This study aimed to identify the characteristics of nine workers newly diagnosed with occupational cholangiocarcinoma. Methods This study was a retrospective study conducted in 13 hospitals and three universities. Clinicopathological findings of nine occupational cholangiocarcinoma patients from seven printing companies in J apan were investigated and compared with 17 cholangiocarcinoma patients clustered in a single printing company in O saka. Results Patient age at diagnosis was 31–57 years. Patients were exposed to 1,2‐dichloropropane and/or dichloromethane. Serum γ‐glutamyl transpeptidase activity was elevated in all patients. Regional dilatation of the intrahepatic bile ducts without tumor‐induced obstruction was observed in two patients. Four patients developed intrahepatic cholangiocarcinoma and five developed hilar cholangiocarcinoma. Biliary intraepithelial neoplasia and/or intraductal papillary neoplasm of the bile duct was observed in four patients with available operative or autopsy specimens. Conclusions Most of these patients with occupational cholangiocarcinoma exhibited typical findings, including high serum γ‐glutamyl transpeptidase activity, regional dilatation of the bile ducts, and precancerous lesions, similar to findings previously reported in 17 occupational cholangiocarcinoma patients in O saka.
Materialart:
Online-Ressource
ISSN:
1868-6974
,
1868-6982
DOI:
10.1002/jhbp.2014.21.issue-11
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
2014
ZDB Id:
2536390-6