In:
Journal of Applied Toxicology, Wiley, Vol. 36, No. 1 ( 2016-01), p. 24-34
Abstract:
Global gene expression profiling was performed in four brain regions in 6‐propyl‐2‐thiouracil (PTU)‐administered young adult rats with hypothyroidism. Among the brain regions, gene expression alterations related to neural development and myelination were most profound in the hippocampal dentate gyrus. Because the gene expression profile of the adult dentate gyrus closely related to neurogenesis, 28‐day toxicity studies looking at gene expression changes in adult hippocampal dentate gyrus may also detect possible developmental neurotoxic effects.
Type of Medium:
Online Resource
ISSN:
0260-437X
,
1099-1263
Language:
English
Publisher:
Wiley
Publication Date:
2016
detail.hit.zdb_id:
1475015-6