In:
Journal of Applied Toxicology, Wiley, Vol. 35, No. 5 ( 2015-05), p. 529-535
Abstract:
This study was performed to clarify whether Mn exposure during development causes proinflammatory responses in the hippocampal dentate gyrus of offspring, involving the Mn‐induced disruption of neurogenesis. Pregnant rats were treated with dietary MnCl 2 · 4H 2 O during gestation and lactation. Their offspring showed increased activated microglia and perivascular macrophages in the dentate hilus and increased proinflammatory cytokines in the hippocampal tissue after 800 ppm MnCl 2 · 4H 2 O, probably involving the disruption of neurogenesis after 800 ppm exposure.
Type of Medium:
Online Resource
ISSN:
0260-437X
,
1099-1263
Language:
English
Publisher:
Wiley
Publication Date:
2015
detail.hit.zdb_id:
1475015-6