In:
International Journal of Cancer, Wiley, Vol. 149, No. 10 ( 2021-11-15), p. 1787-1800
Abstract:
What's new? Gene splicing is a common target of mutation and dysregulation in cancer. The mechanisms underlying the splicing of very small exons, or microexons, and patterns of microexon splicing in cancer, however, remain largely unknown. In this study, transcriptome‐wide profiling of microexon splicing in colorectal cancer (CRC) led to the discovery of 21 differentially spliced microexons. Differential splicing was affected by changes in the expression of splicing factors RBFOX2 and PTBP1, which bound directly to microexon‐containing pre‐mRNAs. Moreover, changes in splicing patterns were associated with CRC metastasis, suggesting that variations in RBFOX2 and PTBP1 expression potentially influence metastatic processes.
Type of Medium:
Online Resource
ISSN:
0020-7136
,
1097-0215
Language:
English
Publisher:
Wiley
Publication Date:
2021
detail.hit.zdb_id:
218257-9
detail.hit.zdb_id:
1474822-8