In:
International Journal of Cancer, Wiley, Vol. 146, No. 11 ( 2020-06), p. 3170-3183
Abstract:
What's new? More than half of all brain metastases show infiltrating rather than displacing growth at the macro‐metastasis/organ parenchyma interface (MMPI), a finding associated with shorter survival. LEF1 is an epithelial‐mesenchymal transition (EMT) transcription factor commonly overexpressed in brain‐colonizing breast cancer cells. Its role in infiltrative MMPIs remains unclear, however. This study identifies LEF1 as a critical regulator of glutathione metabolism aside from its EMT inducer role. LEF1 overexpression induces resistance against glutathione depletion and improves the antioxidative capacity of breast cancer cells. Increased glutathione fitness and reactive oxygen species resistance appear to be more relevant than EMT induction during brain colonization.
Type of Medium:
Online Resource
ISSN:
0020-7136
,
1097-0215
Language:
English
Publisher:
Wiley
Publication Date:
2020
detail.hit.zdb_id:
218257-9
detail.hit.zdb_id:
1474822-8