In:
International Journal of Cancer, Wiley, Vol. 146, No. 6 ( 2020-03-15), p. 1741-1753
Abstract:
What's new? Currently, α‐fetoprotein (AFP) is the most practical screening biomarker for early hepatocellular carcinoma (HCC) detection and prognostic tool for tumor recurrence and patient survival, but the relatively poor sensitivity and specificity remain unsatisfactory. Here, retinol metabolism was found to be closely associated with the malignant transformation of HCC. Retinol and retinal displayed great diagnostic ability for HCC both in liver tissue and serum samples. The two‐metabolite panel could serve as an independent predictor for HCC; low expression of retinol and retinal correlated with decreased survival time. Retinol metabolism thus hold great promise for clinical application in HCC diagnosis and prognosis.
Type of Medium:
Online Resource
ISSN:
0020-7136
,
1097-0215
Language:
English
Publisher:
Wiley
Publication Date:
2020
detail.hit.zdb_id:
218257-9
detail.hit.zdb_id:
1474822-8