In:
International Journal of Cancer, Wiley, Vol. 145, No. 6 ( 2019-09-15), p. 1648-1659
Abstract:
What's new? Tumor‐derived exosomes have raised wide interest as intercellular messengers of oncogenic information serving to prepare a pre‐metastatic niche. The effects of cancer‐derived exosomes on lymphatic network remodeling in sentinel lymph nodes (SLNs) remain unclear, however. Here, the authors demonstrate that colorectal cancer‐derived exosomes promote lymphangiogenesis in SLNs through IRF‐2, which is capable of inducing VEGFC expression in macrophages. This may create a favorable environment for lymph node metastasis. The findings contribute to the understanding of the mechanisms underlying exosomal regulation of the tumor microenvironment and open up new ways to control tumor metastasis.
Type of Medium:
Online Resource
ISSN:
0020-7136
,
1097-0215
Language:
English
Publisher:
Wiley
Publication Date:
2019
detail.hit.zdb_id:
218257-9
detail.hit.zdb_id:
1474822-8