In:
International Journal of Cancer, Wiley, Vol. 144, No. 6 ( 2019-03-15), p. 1345-1355
Abstract:
What's new? Genetic variations in microRNA (miRNA)‐binding regions are suspected to influence tumorigenesis. In this study, in tissues from bladder cancer (BC) patients, the single nucleotide polymorphism rs2073859 (G‐to‐A allele) in the 3’‐UTR miRNA‐135a‐binding site of the oncogene LIM kinase 2 (LIMK2) was associated with gene overexpression and higher clinical grade. A high frequency of rs2073859 A genotypes was detected in BC tissues. In BC cells and mice, LIMK2 overexpression promoted cell proliferation, migration, and invasion and accelerated BC tumor growth. The findings suggest that LIMK2 normally is downregulated by miRNA‐135a and becomes tumorigenic following miRNA‐135a disruption by rs2073859 variant A.
Type of Medium:
Online Resource
ISSN:
0020-7136
,
1097-0215
Language:
English
Publisher:
Wiley
Publication Date:
2019
detail.hit.zdb_id:
218257-9
detail.hit.zdb_id:
1474822-8