In:
International Journal of Cancer, Wiley, Vol. 143, No. 5 ( 2018-09), p. 1134-1142
Abstract:
What's new? The spread of cancer cells to the lungs in osteosarcoma is difficult to control and can fuel further progression of the disease. Little is known, however, about the mechanisms behind lung metastasis in osteosarcoma. Here, comprehensive whole exome sequencing comparing genetic alterations between primary and metastatic osteosarcomas shows that metastatic tumors harbor clones that are unique from those of primary tumors. Specific genetic events were identified in association with tumor progression. In particular, KEAP1 amplification was associated with significantly worse lung metastasis‐free survival, making it a potentially valuable biomarker for increased metastatic risk in osteosarcoma patients.
Type of Medium:
Online Resource
ISSN:
0020-7136
,
1097-0215
Language:
English
Publisher:
Wiley
Publication Date:
2018
detail.hit.zdb_id:
218257-9
detail.hit.zdb_id:
1474822-8