In:
International Journal of Cancer, Wiley, Vol. 140, No. 9 ( 2017-05), p. 2112-2124
Abstract:
What's new? Localized early‐stage head and neck squamous cell carcinoma (HNSCC) is curable through surgical resection. Not infrequently, however, HNSCC returns in the form of locoregional relapse or distant metastases. Here, analyses of patient resection specimens show that clinically occult lymphatic tumor cell dissemination can occur earlier than previously assumed, with disseminated tumor cells (DTCs) already present in UICC stage I and II tumors. Topographical analysis of lymph nodes (LN) harboring DTCs revealed nonrandom distribution following the typical dissemination pattern of HNSCC metastases. The findings warrant investigation of sentinel LN testing and elective neck dissection to prevent HNSCC recurrence.
Type of Medium:
Online Resource
ISSN:
0020-7136
,
1097-0215
Language:
English
Publisher:
Wiley
Publication Date:
2017
detail.hit.zdb_id:
218257-9
detail.hit.zdb_id:
1474822-8