In:
International Journal of Cancer, Wiley, Vol. 139, No. 10 ( 2016-11-15), p. 2261-2269
Abstract:
What's new? Malignant pleural effusion (MPE) often occurs in advanced lung cancer. Immune dysfunction is frequently seen in MPE, but the mechanisms are poorly understood. In this study, the authors found that T cells in MPE display a number of abnormalities, including an increase in inhibitory molecules and impaired cytotoxic activity. These appear to be related to an increase in TGF‐β production by tumor‐associated macrophages (TAMs). These results suggest that targeting the TGF‐β pathway could provide an effective therapeutic strategy for MPE.
Type of Medium:
Online Resource
ISSN:
0020-7136
,
1097-0215
Language:
English
Publisher:
Wiley
Publication Date:
2016
detail.hit.zdb_id:
218257-9
detail.hit.zdb_id:
1474822-8