In:
International Journal of Cancer, Wiley, Vol. 137, No. 7 ( 2015-10), p. 1630-1642
Abstract:
What's New? The prognosis of patients with glioblastoma multiforme (GBM) remains dismal. GBM tumors can modify the immune response, both locally and systemically, which contributes to the aggressive nature of the disease. In this study, the authors found that GBM‐derived extracellular vesicles (EVs) were able to modify the phenotypes of immune cells such as microglia and blood‐derived monocytes in ways that made them more tumor‐supportive. Changes included altered cytokine secretion by macrophages and increased expression of Membrane type 1‐matrix metalloproteinase (MT1‐MMP) by microglia. These results suggest that blocking GBM‐derived EVs may have therapeutic potential.
Type of Medium:
Online Resource
ISSN:
0020-7136
,
1097-0215
Language:
English
Publisher:
Wiley
Publication Date:
2015
detail.hit.zdb_id:
218257-9
detail.hit.zdb_id:
1474822-8