In:
International Journal of Cancer, Wiley, Vol. 136, No. 6 ( 2015-03-15), p. 1333-1340
Abstract:
What's New? Lung cancer pathogenesis is influenced by a variety of factors, including the deregulation of certain microRNAs. This study identifies microRNA‐153 (miR‐153) as a novel player in lung cancer. MiR‐153 expression was found to be decreased in lung cancer tissue, and when overexpressed exogenously, miR‐153 inhibited AKT protein expression, blocked cell proliferation and migration, and promoted apoptosis. Lung cancer cells with low endogenous miR‐153 levels displayed increased sensitivity to exogenous miR‐153 overexpression. Experiments in vivo reveal that miR‐153 overexpression suppresses tumor growth.
Type of Medium:
Online Resource
ISSN:
0020-7136
,
1097-0215
Language:
English
Publisher:
Wiley
Publication Date:
2015
detail.hit.zdb_id:
218257-9
detail.hit.zdb_id:
1474822-8