In:
International Journal of Cancer, Wiley, Vol. 135, No. 9 ( 2014-11), p. 2054-2064
Abstract:
What's new? Chromaffin cell tumors can result from mutations in a number of different genes, and they show a variety of characteristics. In this study, the authors looked at patient samples to figure out how mutations in the Myc‐associated factor X (MAX) gene influences gene expression patterns in the tumors. They also manipulated cell line models to see how the interactions of MAX, HIF1α, and HIF2α affect tumor characteristics. They found that tumors resulting from MAX mutations have a distinctive gene expression profile and phenotypic characteristics. HIF1α and HIF2α have opposing influences in the cell, they found, and the relative expression of these two can alter the characteristics of the tumor.
Type of Medium:
Online Resource
ISSN:
0020-7136
,
1097-0215
Language:
English
Publisher:
Wiley
Publication Date:
2014
detail.hit.zdb_id:
218257-9
detail.hit.zdb_id:
1474822-8