In:
International Journal of Cancer, Wiley, Vol. 134, No. 6 ( 2014-03-15), p. 1511-1516
Kurzfassung:
What's new? JUNB is a subunit of the AP‐1 transcription factor and a critical activator of Vegfa , the master regulator of angiogenesis. Here, the authors used conditional Junb knockout mice to define the role of stromal JUNB on tumor growth and angiogenesis. Surprisingly, although tumor‐derived JUNB is known to critically regulate these properties, stromal, host‐derived JUNB is dispensable for these processes. The study indicates that loss of stromal JUNB is well compensated by the tumor itself as well as infiltrating immune cells that provide pro‐angiogenic factors and matrix metalloproteinases otherwise induced by JUNB expression in the tumor microenvironment.
Materialart:
Online-Ressource
ISSN:
0020-7136
,
1097-0215
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
2014
ZDB Id:
218257-9
ZDB Id:
1474822-8