In:
Head & Neck, Wiley, Vol. 43, No. 12 ( 2021-12), p. 3707-3719
Abstract:
The prognostic impact of hsa‐miRNA‐182‐5p in oral cancer remains unexplored. Therefore, the aim of this study was to investigate the prognostic value of hsa‐miRNA‐182‐5p and its predicted target kinectin 1 (KTN1 ) in oral squamous cell carcinoma (OSCC). Method Expression level of hsa‐miRNA‐182‐5p was analyzed in tumor tissue ( n = 36) and healthy oral mucosal tissue (n = 17) using quantitative real‐time polymerase chain reaction. Protein level of the predicted target KTN1 was detected via immunohistochemistry. Results were validated in a cohort of The Cancer Genome Atlas (TCGA). Results After dividing the data into a subgroup with high and low hsa‐miRNA‐182‐5p expression level, a significant better overall ( p = 0.016), recurrence‐free ( p = 0.009), and progression‐free survival ( p = 0.004) was observed in an upregulation of hsa‐miRNA‐182‐5p. Staining intensity of KTN1 showed a reciprocal impact on the prognosis. Validation in a TCGA cohort confirmed these results. Conclusion Our results indicate hsa‐miRNA‐182‐5p and KTN1 as potential biomarkers for OSCC.
Type of Medium:
Online Resource
ISSN:
1043-3074
,
1097-0347
Language:
English
Publisher:
Wiley
Publication Date:
2021
detail.hit.zdb_id:
2001440-5
detail.hit.zdb_id:
645165-2