In:
Head & Neck, Wiley, Vol. 43, No. 11 ( 2021-11), p. 3314-3323
Abstract:
Precise risk stratification models are necessary to determine patient selection for deintensifying treatment trials in human papilloma virus (HPV)‐associated oropharyngeal squamous cell cancer (HPV+ OPSCC). Methods We examined 526 cases with OPSCC treated at our department between 2002 and 2017. Every patient was classified after the 7th and 8th edition UICC staging manual. For HPV+ OPSCC, we calculated a simple risk score with four risk groups based on multivariable Cox regression analysis of clinical and lifestyle parameters (UICC 8th edition stage, tobacco/alcohol abuse, age, gender). Results Two hundred and thirty‐nine patients with OPSCC (45.4%) showed a positive histological HPV status. In comparison to UICC 8th edition stages, our proposed risk model showed a tendency for better stratification between risk strata I/III, I/IV, and II/IV (each p 〈 0.002) and I/II, II/III, and III/IV (each p 〈 0.09). Conclusion Age, gender, tobacco, and alcohol abuse should be added to the current UICC staging system in order to improve risk stratification in HPV+ OPSCC.
Type of Medium:
Online Resource
ISSN:
1043-3074
,
1097-0347
Language:
English
Publisher:
Wiley
Publication Date:
2021
detail.hit.zdb_id:
2001440-5