In:
Head & Neck, Wiley, Vol. 38, No. S1 ( 2016-04)
Abstract:
The purpose of this study was to assess outcomes of patients with orbital carcinomas treated with orbital exenteration and intensity‐modulated radiation therapy (IMRT). Methods Twenty‐nine patients were treated with orbital exenteration and postoperative IMRT between 2002 through 2011; their medical records were retrospectively reviewed. Results Adenoid cystic carcinoma represented the most common histology (41%) followed by squamous cell carcinoma (21%). Perineural invasion (PNI) was identified in 22 patients (76%). The median radiation dose was 60 Gy (range, 60–70). Seven patients (24%) received neck radiation. The median follow‐up was 43 months (range, 5–102 months). Five‐year local control, overall survival (OS), and disease‐free survival rates were 83%, 60%, and 55%, respectively. PNI ( p = .01) and especially involvement of a named nerve ( p = .001) significantly correlated with worse OS. Conclusion Favorable disease control rates for orbital carcinomas are achievable with IMRT after orbital exenteration even for patients with advanced disease. Toxicity for the contralateral eye was minimal. © 2015 Wiley Periodicals, Inc. Head Neck 38 : E580–E587, 2016
Type of Medium:
Online Resource
ISSN:
1043-3074
,
1097-0347
Language:
English
Publisher:
Wiley
Publication Date:
2016
detail.hit.zdb_id:
2001440-5