In:
International Journal of Geriatric Psychiatry, Wiley, Vol. 33, No. 10 ( 2018-10), p. 1305-1311
Abstract:
To investigate the association between chronic subsyndromal symptoms of depression (SSD), cerebrospinal fluid (CSF) biomarkers, and neuropsychological performance in individuals with mild cognitive impairment (MCI). Methods Participants included 238 older adults diagnosed with MCI from the Alzheimer's Disease Neuroimaging Initiative repository with cognitive and CSF amyloid beta (Aβ 1–42 ), total tau (t‐tau), and phosphorylated tau (p‐tau) data. The Neuropsychiatric Inventory identified individuals with chronic endorsement (SSD group N = 80) or no endorsement (non‐SSD group N = 158) of depressive symptoms across timepoints. CSF biomarker and cognitive performance were evaluated with linear regression models adjusting for age, education, gender, APOE genotype, global cognitive status, and SSD group. Results As compared to the non‐SSD group, the SSD group displayed lower CSF Aβ 1–42 levels (β = −24.293, S.E. = 6.345, P 〈 0.001). No group differences were observed for CSF t‐tau ( P = 0.497) or p‐tau levels ( P = 0.392). Lower CSF Aβ 1–42 levels were associated with poorer performance on learning (β = 0.041, S.E. = 0.018, P = 0.021) and memory (β = −0.012, S.E. = 0.005, P = 0.031) measures, whereas higher CSF t‐tau levels were associated with poorer performance on measures of global cognition (β = 0.022, S.E = 0.008, P = 0.007) and language (β = −0.010, S.E = 0.004, P = 0.019). SSD was independently associated with diminished global cognition, learning and memory, language, and executive function performance over and above the effects of CSF biomarkers (all P 〈 0.05). Conclusions MCI participants with SSD displayed diminished CSF Aβ 1–42 levels but did not differ from non‐SSD controls in CSF tau levels. Additionally, CSF biomarkers and SSD independently accounted for variance in cognitive performance, suggesting that these factors may uniquely confer cognitive risk in MCI.
Type of Medium:
Online Resource
ISSN:
0885-6230
,
1099-1166
Language:
English
Publisher:
Wiley
Publication Date:
2018
detail.hit.zdb_id:
806736-3
detail.hit.zdb_id:
1500455-7
