In:
European Journal of Organic Chemistry, Wiley, Vol. 2021, No. 41 ( 2021-11-08), p. 5609-5617
Abstract:
A one‐pot synthesis of 2‐amido‐3‐bromobenzo[ b ]thiophenes based on C−N coupling and oxidative bromocyclization reactions was developed. This enables a modular approach to obtain diverse substituents at the C2 position of benzothiophenes by employing structurally modified sulfonamides. Oxidative cyclization was driven by Selectfluor and represents a previously unreported recycling method for the bromide anion byproducts of the C−N bond coupling step. The details of the study are described fully herein.
Type of Medium:
Online Resource
ISSN:
1434-193X
,
1099-0690
DOI:
10.1002/ejoc.v2021.41
DOI:
10.1002/ejoc.202101093
Language:
English
Publisher:
Wiley
Publication Date:
2021
detail.hit.zdb_id:
1475010-7