In:
European Journal of Organic Chemistry, Wiley, Vol. 2016, No. 21 ( 2016-07), p. 3462-3472
Abstract:
Conotoxins are disulfide‐rich peptides found in the venoms of marine snails of the genus Conus . They have attracted great attention from the pharmaceutical industry because of their potential uses as drug leads, but like most peptides, conotoxins are susceptible to proteolysis and typically are not orally bioavailable. Here we discuss approaches that have been used to stabilise conotoxins to improve their potential pharmaceutical use. Specifically, we focus on the use of backbone cyclisation to improve their stability in biological fluids. The Microreview provides an introduction to the various classes of conotoxins, including their frameworks (cysteine patterns) and a background on the receptors that they interact with, as well as an analysis of the binding interactions between conotoxins and their receptors.
Type of Medium:
Online Resource
ISSN:
1434-193X
,
1099-0690
DOI:
10.1002/ejoc.v2016.21
DOI:
10.1002/ejoc.201600402
Language:
English
Publisher:
Wiley
Publication Date:
2016
detail.hit.zdb_id:
1475010-7
