In:
European Journal of Organic Chemistry, Wiley, Vol. 2008, No. 33 ( 2008-11), p. 5493-5506
Abstract:
The enantioselective decarboxylative protonation (EDP) of malonic or acetoacetic acid derivatives is a synthetic methodology by which the chirality of the product is generated during the enol/enolate protonation step. Although EDP is a century‐old reaction, it has not received much attention until recently. This review focuses on the EDP as an alternative to the strong‐base‐mediated deprotonation/asymmetric reprotonation for the stereocontrol of C–H bond formation. The diverse synthetic approaches are classified according to the type of catalysis used, which are organic, metallic or enzymatic.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
Type of Medium:
Online Resource
ISSN:
1434-193X
,
1099-0690
DOI:
10.1002/ejoc.v2008:33
DOI:
10.1002/ejoc.200800759
Language:
English
Publisher:
Wiley
Publication Date:
2008
detail.hit.zdb_id:
1410000-9
detail.hit.zdb_id:
1475010-7