In:
European Journal of Immunology, Wiley, Vol. 49, No. 1 ( 2019-01), p. 121-132
Abstract:
The interdependence of posttranscriptional gene regulation via miRNA and transcriptional regulatory networks in lymphocyte development is poorly understood. Here, we identified miR‐191 as direct upstream modulator of a transcriptional module comprising the transcription factors Foxp1, E2A, and Egr1. Deletion as well as ectopic expression of miR‐191 resulted in developmental arrest in B lineage cells, indicating that fine tuning of the combined expression levels of Foxp1, E2A, and Egr1, which in turn control somatic recombination and cytokine‐driven expansion, constitutes a prerequisite for efficient B‐cell development. In conclusion, we propose that miR‐191 acts as a rheostat in B‐cell development by fine tuning a key transcriptional program.
Type of Medium:
Online Resource
ISSN:
0014-2980
,
1521-4141
DOI:
10.1002/eji.201847660
Language:
English
Publisher:
Wiley
Publication Date:
2019
detail.hit.zdb_id:
120108-6
detail.hit.zdb_id:
1491907-2