In:
European Journal of Immunology, Wiley, Vol. 38, No. 6 ( 2008-06), p. 1487-1492
Abstract:
Epithelial cell‐derived thymic stromal lymphopoietin (TSLP) is a master switch for asthma or atopic dermatitis by inducing a dendritic cell‐mediated Th2‐type allergic inflammation. Allergic rhinitis is also pathologically characterized by Th2‐type allergic inflammation. This study demonstrates that mast cells regulate the epithelial TSLP expression in allergic rhinitis. TSLP expression was found to be up‐regulated predominantly in the nasal epithelium in the ovalbumin (OVA)‐sensitized and ‐nasally challenged mouse model of allergic rhinitis, which was abolished in mast cell‐deficient WBB6F1‐W/W v in comparison with control WBB6F1‐+/+ mice. Similarly, the epithelial TSLP expression was reduced in Fc receptor γ chain (FcγR)‐deficient mice, where the high‐affinity IgE receptor (FcϵRI) is not expressed on mast cells, in comparison with control C57BL/6 mice. Furthermore, the administration of neutralizing TSLP antibody during the challenge phase of OVA inhibited the development of allergic rhinitis. These results suggest that the direct stimulation of epithelial cells by antigens alone may not be sufficient to induce TSLP expression in the nasal epithelium, and that mast cell regulation of epithelial TSLP expression, possibly via FcϵRI, plays an important role in the development of allergic rhinitis.
Type of Medium:
Online Resource
ISSN:
0014-2980
,
1521-4141
DOI:
10.1002/eji.200737809
Language:
English
Publisher:
Wiley
Publication Date:
2008
detail.hit.zdb_id:
120108-6
detail.hit.zdb_id:
1491907-2
