In:
Developmental Dynamics, Wiley, Vol. 245, No. 11 ( 2016-11), p. 1107-1123
Kurzfassung:
Germ line deletion of 14‐3‐3ε in the mouse leads to a very high incidence of multiple cardiac malformations. Malalignment of both the outflow tract (OFT) and the atrioventricular (AV) endocardial cushions, leading to tricuspid stenosis/atresia and mitral valve abnormalities. In addition to muscular VSDs and myocardial non‐compaction, we identified epicardial blebbing and deep endocardial recesses. Abnormal pharyngeal arch artery patterning and defects in coronary vasculature remodeling. Abnormal patterning of p27 kip1 in the endocardium might trigger some of the described developmental malformations through the disturbance of epithelial‐to‐mesenchymal transformation.
Materialart:
Online-Ressource
ISSN:
1058-8388
,
1097-0177
DOI:
10.1002/dvdy.v245.11
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
2016
ZDB Id:
1473797-8
SSG:
12