In:
Chemistry & Biodiversity, Wiley, Vol. 21, No. 5 ( 2024-05)
Abstract:
The chemical investigation of the stems of Knema globularia led to the isolation of two new benzoquinones derivatives, embenones A and B ( 1 and 2 ), along with three known compounds ( 3–5 ). The structures of the isolated compounds were determined using spectroscopic techniques, including HRESIMS, 1D and 2D NMR, in conjunction with comparison to existing literature data. Compounds 1 and 2 represent new carbon skeletons in nature. Furthermore, all isolated compounds were evaluated for their α ‐glucosidase inhibitory activity, with compounds 1–3 exhibiting superior potency relative to the positive control (acarbose, IC 50 331 μ M). Their IC 50 values ranged from 1.40 to 96.1 μ M.
Type of Medium:
Online Resource
ISSN:
1612-1872
,
1612-1880
DOI:
10.1002/cbdv.202400380
Language:
English
Publisher:
Wiley
Publication Date:
2024
detail.hit.zdb_id:
2136784-X
detail.hit.zdb_id:
2139001-0
SSG:
12