In:
Cancer Medicine, Wiley, Vol. 5, No. 12 ( 2016-12), p. 3579-3585
Abstract:
Invasive mucinous lung adenocarcinoma ( IMA ) is a rare subtype of lung adenocarcinoma with no effective treatment option in advanced disease. KRAS mutations occur in 28–87% of the cases. NRG 1 fusions were recently discovered in KRAS ‐negative IMA cases and otherwise negative for known driver oncogenes and could represent an attractive therapeutic target. Published data suggest that NRG 1 fusions occur essentially in nonsmoking Asian women. From an IMA cohort of 25 French patients of known ethnicity, driver oncogenes EGFR , KRAS , BRAF , ERBB 2 mutations, and ALK and ROS 1 rearrangements presence were analyzed. In the IMA samples remaining negative for these driver oncogenes, an NRG 1 rearrangement detection was performed by FISH . A driver oncogene was identified in 14/25 IMA , namely 12 KRAS mutations (48%), one ROS 1 rearrangement (4%), and one ALK rearrangement (4%). The detection of NRG 1 rearrangement by FISH was conducted in the 11 pan‐negative IMA . One sample was NRG 1 FISH ‐positive and 100% of the tumor nuclei analyzed were positive. This NRG 1 ‐positive patient was a 61‐year‐old nonsmoking woman of Vietnamese ethnicity and was the sole patient of Asian ethnicity of the cohort. She died 6 months after the diagnosis with a pulmonary multifocal disease. NRG 1 FISH detection should be considered in patients with IMA pan‐negative for known driver oncogenes. These results might suggest that NRG 1 fusion is more frequent in IMA from Asian patient. Larger studies are needed.
Type of Medium:
Online Resource
ISSN:
2045-7634
,
2045-7634
DOI:
10.1002/cam4.2016.5.issue-12
Language:
English
Publisher:
Wiley
Publication Date:
2016
detail.hit.zdb_id:
2659751-2
