In:
Cancer Medicine, Wiley, Vol. 11, No. 24 ( 2022-12), p. 4880-4888
Abstract:
Immune checkpoint inhibitors ( ICIs ) play an increasingly important role in the treatment of primary liver cancer ( PLC ). Some patients with PLC experience symptoms of splenomegaly. Splenomegaly may affect the efficacy of ICIs due to an imbalance of the immune microenvironment. Currently, there is a lack of evidence on the relationship between splenomegaly and prognosis in patients with PLC treated with ICIs . This study analyzed the relationship between splenomegaly and prognosis in patients with PLC treated with ICIs. Methods In this retrospective cohort study of 161 patients with PLC treated with ICIs , splenomegaly was diagnosed using computed tomography or magnetic resonance imaging and the impact of splenomegaly on patient survival was analyzed. Results Through univariate and multivariate Cox regression analyses, we determined that splenomegaly was associated with shortened overall survival ( p = 0.002) and progression‐free survival ( p = 0.013) in patients with PLC treated with ICIs . Kaplan–Meier analysis further validated our results. The overall survival and progression‐free survival of patients with splenomegaly were significantly shorter than those of patients without splenomegaly ( p 〈 0.01 and p = 0.02, respectively). Conclusions We concluded that splenomegaly was a predictor of prognosis in patients with PLC treated with ICIs . This is the first study to report this important finding.
Type of Medium:
Online Resource
ISSN:
2045-7634
,
2045-7634
Language:
English
Publisher:
Wiley
Publication Date:
2022
detail.hit.zdb_id:
2659751-2
