In:
Angewandte Chemie International Edition, Wiley, Vol. 57, No. 43 ( 2018-10-22), p. 14101-14105
Abstract:
Tumor‐specific phototheranostics is conducive to realizing precise cancer therapy. Herein, a novel tumor microenvironment (TME)‐responsive phototheranostic paradigm based on the combination of semiconducting polymer brushes and polyoxometalate clusters (SPB@POM) is rationally designed. The acidic TME could drive the self‐assembly of SPB@POM into bigger aggregates for enhanced tumor retention and accumulation, while the reducing TME could significantly enhance the NIR absorption of SPB@POM for significant improvement of photoacoustic imaging contrast and photothermal therapy efficacy. Therefore, the smart pH/glutathione (GSH)‐responsive SPB@POM allows for remarkable phototheranostic enhancement under the unique TME, which has potential for precise tumor‐specific phototheranostics with minimal side effects.
Type of Medium:
Online Resource
ISSN:
1433-7851
,
1521-3773
DOI:
10.1002/anie.201808074
Language:
English
Publisher:
Wiley
Publication Date:
2018
detail.hit.zdb_id:
2011836-3
detail.hit.zdb_id:
123227-7