In:
Angewandte Chemie, Wiley, Vol. 132, No. 41 ( 2020-10-05), p. 18198-18203
Abstract:
Ca 2+ , a ubiquitous but nuanced modulator of cellular physiology, is meticulously controlled intracellularly. However, intracellular Ca 2+ regulation, such as mitochondrial Ca 2+ buffering capacity, can be disrupted by 1 O 2 . Thus, the intracellular Ca 2+ overload, which is recognized as one of the important cell pro‐death factors, can be logically achieved by the synergism of 1 O 2 with exogenous Ca 2+ delivery. Reported herein is a nanoscale covalent organic framework (NCOF)‐based nanoagent, namely CaCO 3 @COF‐BODIPY‐2I@GAG ( 4 ), which is embedded with CaCO 3 nanoparticle (NP) and surface‐decorated with BODIPY‐2I as photosensitizer (PS) and glycosaminoglycan (GAG) targeting agent for CD44 receptors on digestive tract tumor cells. Under illumination, the light‐triggered 1 O 2 not only kills the tumor cells directly, but also leads to their mitochondrial dysfunction and Ca 2+ overload. An enhanced antitumor efficiency is achieved via photodynamic therapy (PDT) and Ca 2+ overload synergistic therapy.
Type of Medium:
Online Resource
ISSN:
0044-8249
,
1521-3757
DOI:
10.1002/ange.v132.41
DOI:
10.1002/ange.202008055
Language:
English
Publisher:
Wiley
Publication Date:
2020
detail.hit.zdb_id:
506609-8
detail.hit.zdb_id:
1479266-7
