In:
Annals of Neurology, Wiley, Vol. 58, No. 2 ( 2005-08), p. 331-337
Abstract:
H untington's disease (HD) is a progressive disorder with no known cure. We report two‐year postoperative positron emission tomography (PET) data from 7 HD patients who underwent intrastriatal fetal transplantation. Patients showed widespread reductions in glucose uptake with no significant change over 2 years. Dopamine receptor binding was significantly reduced in HD striatum. D1 binding did not change significantly following transplantation, but there was a significant loss of D2 binding. These findings may reflect loss of graft viability and/or disease progression. There was no significant relationship between changes in PET and clinical function. In summary, there was no benefit from transplantation. Ann Neurol 2005;58:331–337
Type of Medium:
Online Resource
ISSN:
0364-5134
,
1531-8249
Language:
English
Publisher:
Wiley
Publication Date:
2005
detail.hit.zdb_id:
80362-5
detail.hit.zdb_id:
2037912-2