In:
Advanced Synthesis & Catalysis, Wiley, Vol. 363, No. 12 ( 2021-06-21), p. 3018-3024
Abstract:
A [4+3] annulation of 2‐ylideneoxindoles with crotonate‐derived sulfur ylides has been developed. A series of oxepino[3,2‐ b ]indoles were prepared in moderate to excellent yields (62‐93%) under mild conditions. Moreover, the synthetic oxepino[3,2‐ b ] indoles can be further transformed into more complex cyclopropa[5,6] oxepino[3,2‐ b ]indoles via a [2+1] cyclopropanation. In addition, the synthetic compounds show certain antiproliferative activity against K562 and MCF‐7 cells, and its IC 50 values for these two kinds of tumor cells up to 5.40±0.88 μM and 18.41±0.50 μM, respectively. magnified image
Type of Medium:
Online Resource
ISSN:
1615-4150
,
1615-4169
DOI:
10.1002/adsc.v363.12
DOI:
10.1002/adsc.202001580
Language:
English
Publisher:
Wiley
Publication Date:
2021
detail.hit.zdb_id:
2041384-1
detail.hit.zdb_id:
2033084-4