In:
Advanced Synthesis & Catalysis, Wiley, Vol. 361, No. 23 ( 2019-12-03), p. 5328-5333
Abstract:
The first example of bifunctional oxindole‐chromone C3 synthon directed organocatalytic cascade cycloaddition reaction is developed, serving as a fruitful strategy for the facile access of optically active tetrahydrocyclopenta[b]chromanone bearing one spirooxindole with five contiguous stereocenters. All the products are smoothly obtained with up to 83% yield, 〉 20:1 d.r. and 〉 99% ee. This is also the first asymmetric catalytic construction of tetrahydrocyclopenta[b] chromanone and tetrahydrocyclopenta[b] chromanone‐spirooxindole scaffold, thus to facilitate the search for new bioactive entities. magnified image
Type of Medium:
Online Resource
ISSN:
1615-4150
,
1615-4169
DOI:
10.1002/adsc.v361.23
DOI:
10.1002/adsc.201901091
Language:
English
Publisher:
Wiley
Publication Date:
2019
detail.hit.zdb_id:
2041384-1
detail.hit.zdb_id:
2033084-4