In:
Cancer Research, American Association for Cancer Research (AACR), Vol. 75, No. 1_Supplement ( 2015-01-01), p. B49-B49
Kurzfassung:
Background: Long thought to function only as an inert energy storage depot, the role of adipose tissue in breast tumorigenesis has been largely ignored. In light of increasing rates of obesity and use of breast conserving therapy and autologous fat grafting, improved understanding of the role of adipose in tumor etiology is crucial. Methods: Adipose adjacent to and distant from invasive breast tumors (n=20), or adjacent to non-malignant diagnoses (n=20) was laser microdissected from post-menopausal women. Gene expression data were generated using microarrays and data analyzed to identify significant patterns of differential expression between adipose groups, at the individual gene and molecular pathway level. Results: Pathway analysis revealed significant differences in immune response between non-malignant, distant and tumor adjacent adipose, with the highest response in tumor-adjacent and lowest in non-malignant adipose. Adipose from invasive breasts exhibits increased expression in anti-inflammatory genes, such as MARCO and VSIG4, while genes differentially expressed between tumor-adjacent and distant adipose such as SPP1, RRM2 and MMP9, are associated with increased cellular proliferation, invasion, and angiogenesis. Conclusions: Gene expression levels differ in breast adipose, depending on presence of or proximity to tumor cells. Heightened immunotolerance in adipose from invasive breasts provides a microenvironment favorable to tumorigenesis. In addition, tumor-adjacent adipose demonstrates expression of genes associated with tumor growth and progression. Together, these data suggest that adipose is not an inert component of the breast microenvironment but plays an active role in tumorigenesis. Citation Format: William C. Yarina, Lori A. Field, Brenda Deyarmin, Ryan van Laar, Jeffrey A. Hooke, Craig D. Shriver, Rachel E. Ellsworth. Molecular characterization of breast tumor-associated adipose. [abstract]. In: Abstracts: AACR Special Conference on Cellular Heterogeneity in the Tumor Microenvironment; 2014 Feb 26-Mar 1; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2015;75(1 Suppl):Abstract nr B49. doi:10.1158/1538-7445.CHTME14-B49
Materialart:
Online-Ressource
ISSN:
0008-5472
,
1538-7445
DOI:
10.1158/1538-7445.CHTME14-B49
Sprache:
Englisch
Verlag:
American Association for Cancer Research (AACR)
Publikationsdatum:
2015
ZDB Id:
2036785-5
ZDB Id:
1432-1
ZDB Id:
410466-3
