In:
International Journal of Cancer, Wiley, Vol. 146, No. 9 ( 2020-05), p. 2619-2627
Kurzfassung:
What's new? To date, prognostic biomarkers for prostate cancer (PCa) patients with aggressive disease are still lacking. Neuropilin‐2 (NRP2) has previously been involved in intracellular trafficking, anti‐apoptotic signaling, and autophagy, indicating a potential role in PCa progression. This large cohort study demonstrates an association between NRP2 protein levels in PCa tissues and cancer‐specific survival in patients with localized PCa treated by radical prostatectomy. NRP2 is associated with a worse outcome, especially in high‐risk PCa patients and patients with negative ERG status. NRP2 thus emerges as an independent prognostic biomarker for aggressive PCa and might become a potential target for future therapy strategies.
Materialart:
Online-Ressource
ISSN:
0020-7136
,
1097-0215
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
2020
ZDB Id:
218257-9
ZDB Id:
1474822-8