GLORIA

GEOMAR Library Ocean Research Information Access

X

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Online Resource
    Online Resource
    Assisting Mother Nature in postnatal chemoreceptor maturation
    American Physiological Society ; 2008
    In:  Journal of Applied Physiology Vol. 104, No. 5 ( 2008-05), p. 1260-1261
    Details
    In: Journal of Applied Physiology, American Physiological Society, Vol. 104, No. 5 ( 2008-05), p. 1260-1261
    Type of Medium: Online Resource
    ISSN: 8750-7587 , 1522-1601
    URL: Article
    DOI: 10.1152/japplphysiol.90312.2008
    RVK:
    WA 15000
    RVK:
    XA 52094
    Language: English
    Publisher: American Physiological Society
    Publication Date: 2008
    detail.hit.zdb_id: 1404365-8
    SSG: 12
    SSG: 31
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 2
    Online Resource
    Online Resource
    Nature of pulmonary hypertension in canine oleic acid pulmonary edema
    American Physiological Society ; 1990
    In:  Journal of Applied Physiology Vol. 69, No. 1 ( 1990-07-01), p. 293-298
    Details
    In: Journal of Applied Physiology, American Physiological Society, Vol. 69, No. 1 ( 1990-07-01), p. 293-298
    Abstract: It has recently been suggested that pulmonary hypertension secondary to oleic acid lung injury mainly results from an increase in the critical closing pressure of the pulmonary vessels [Boiteau et al., Am. J. Physiol. 251 (Heart Circ. Physiol. 20): H1163-H1170, 1986]. To further test this hypothesis, we studied 1) the pulmonary arterial pressure- (Ppa) flow (Q) relationship with left atrial pressure (Pla) kept constant (n = 7) and 2) the Ppa-Pla relationship with Q kept constant (n = 9) in intact anesthetized an d ventilated dogs before and after lung injury induced by oleic acid (0.09 ml/kg iv). Q was manipulated by use of a femoral arteriovenous bypass and a balloon catheter inserted in the inferior vena cava. Pla was manipulated with a balloon catheter placed by thoracotomy in the left atrium. Ppa-Q plots were rectilinear before as well as after oleic acid. Before oleic acid, the extrapolated pressure intercept of the Ppa-Q plots approximated Pla. Oleic acid administration resulted in a parallel shift of the Ppa-Q plots to higher pressure; i.e., the pressure intercept increased, whereas the slope was not modified. Increasing Pla at constant Q before oleic acid led to a proportional augmentation of Ppa. After oleic acid, however, changes in Pla over the same range affected Ppa only at the highest levels of Pla. These results suggest that oleic acid lung injury increases the critical closing pressure that exceeds Pla, becomes the effective outflow pressure of the pulmonary circulation, and is responsible for the pulmonary hypertension.
    Type of Medium: Online Resource
    ISSN: 8750-7587 , 1522-1601
    URL: Article
    DOI: 10.1152/jappl.1990.69.1.293
    RVK:
    WA 15000
    RVK:
    XA 52094
    Language: English
    Publisher: American Physiological Society
    Publication Date: 1990
    detail.hit.zdb_id: 1404365-8
    SSG: 12
    SSG: 31
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 3
    Online Resource
    Online Resource
    Nature of the mammalian ciliary metachronal wave
    American Physiological Society ; 1993
    In:  Journal of Applied Physiology Vol. 75, No. 1 ( 1993-07-01), p. 458-467
    Details
    In: Journal of Applied Physiology, American Physiological Society, Vol. 75, No. 1 ( 1993-07-01), p. 458-467
    Abstract: The temporal and spatial coordination of ciliary beat (metachronicity) is fundamental to effective mucociliary transport. Metachronal wave period (MWP) and ciliary beat frequency (CBF) of fresh excised sheep and canine tracheal epithelial tissues were measured with the use of a newly developed alternating focal spot laser light scattering system. MWP was determined from cross correlation of the heterodyne signals from the alternating focal spots. CBF was determined by autocorrelation of the heterodyne signals from each of the spots. MWP and CBF were measured in four sheep tracheal epithelial tissues with the use of longitudinal interfocal spot distances of 6 and 18 microns. In three canine tracheal epithelial tissues MWP and CBF were measured both longitudinally and circumferentially with interfocal spot distances of 5, 15, 65, 87, and 96 microns. For the sheep tracheal epithelial tissues the mean CBF was 5.9 +/- 0.4 Hz (mean of means; range 3.6 +/- 0.5 to 9.9 +/- 1.5 Hz), whereas the mean MWPs for 6- and 18-microns interfocal spot distances were 0.50 +/- 0.1 and 0.47 +/- 0.1 s, respectively. For the canine tracheal epithelial tissues the mean CBF was 4.0 +/- 0.2 Hz (2.0 +/- 0.8 to 7.2 +/- 3.2 Hz), whereas the mean longitudinal MWP was 1.5 s and the mean circumferential MWP was 2.1 s. Geometric combination of the MWP components leads to a derived MWP of 2.6 s with a propagation direction of 54 degrees with respect to the longitudinal axis of the trachea. MWP was found to be episode modulated with 12- to 20-min intervals in the longitudinal direction, but modulation was not as apparent in the circumferential direction. These data suggest that MWP and CBF are regulated by separate intracellular, intercellular, and intraciliary mechanisms.
    Type of Medium: Online Resource
    ISSN: 8750-7587 , 1522-1601
    URL: Article
    DOI: 10.1152/jappl.1993.75.1.458
    RVK:
    WA 15000
    RVK:
    XA 52094
    Language: English
    Publisher: American Physiological Society
    Publication Date: 1993
    detail.hit.zdb_id: 1404365-8
    SSG: 12
    SSG: 31
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 4
    Online Resource
    Online Resource
    Nature and site of action of endogenous nitric oxide in vasculature of isolated pig lungs
    American Physiological Society ; 1997
    In:  Journal of Applied Physiology Vol. 82, No. 1 ( 1997-01-01), p. 23-31
    Details
    In: Journal of Applied Physiology, American Physiological Society, Vol. 82, No. 1 ( 1997-01-01), p. 23-31
    Abstract: Cremona, George, Tim Higenbottam, Motoshi Takao, Edward A. Bower, and Leslie W. Hall. Nature and site of action of endogenous nitric oxide in vasculature of isolated pig lungs. J. Appl. Physiol. 82(1): 23–31, 1997.—The site of action of endogenous and exogenous nitric oxide (NO) in isolated pig lungs was investigated by using arterial, double, and venous occlusion, which allowed precapillary, postcapillary, and venous segments to be partitioned into arterial, precapillary, postcapillary, and venous segments. N G -nitro-l-arginine (l-NNA; 10 −5 M) increased resistance in the arterial (35 ± 6.6%, P = 0.003), precapillary (39.3 ± 5.1%, P = 0.001), and venous (18.3 ± 4.8%, P = 0.01) segments, respectively. Sodium nitroprusside (10 −5 M) and NO (80 parts/million) reversed the effects ofl-NNA. Total pulmonary vascular resistance fell with increasing flow, due to a fall in precapillary resistance and dynamic resistance, and was significantly lower than mean total resistance.l-NNA increased the resistances but did not alter the pattern of the pressure-flow relationships. It is concluded that, in isolated pig lungs, the effect of endogenous NO seems to be dependent on flow in the arterial segment and independent of flow in the precapillary segment, but variation of its release does not appear to be fundamental to accommodation to changes in steady flow.
    Type of Medium: Online Resource
    ISSN: 8750-7587 , 1522-1601
    URL: Article
    DOI: 10.1152/jappl.1997.82.1.23
    RVK:
    WA 15000
    RVK:
    XA 52094
    Language: English
    Publisher: American Physiological Society
    Publication Date: 1997
    detail.hit.zdb_id: 1404365-8
    SSG: 12
    SSG: 31
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 5
    Online Resource
    Online Resource
    Nature and distribution of vascular resistance in hypoxic pig lungs
    American Physiological Society ; 1985
    In:  Journal of Applied Physiology Vol. 59, No. 6 ( 1985-12-01), p. 1891-1901
    Details
    In: Journal of Applied Physiology, American Physiological Society, Vol. 59, No. 6 ( 1985-12-01), p. 1891-1901
    Abstract: We used the vascular occlusion technique in pig lungs isolated in situ to describe the effects of hypoxia on the distribution of vascular resistance and to determine whether the resistive elements defined by this technique behaved as ohmic or Starling resistors during changes in flow at constant outflow pressure, changes in outflow pressure at constant flow, and reversal of flow. During normoxia, the largest pressure gradient occurred across the middle compliant region of the vasculature (delta Pm). The major effect of hypoxia was to increase delta Pm and the gradient across the relatively noncompliant arterial region (delta Pa). The gradient across the noncompliant venous region (delta Pv) changed only slightly, if at all. Both delta Pa and delta Pv increased with flow but delta Pm decreased. The pressure at the arterial end of the middle region was independent of flow and, when outflow pressure was increased, did not increase until the outflow pressure of the middle region exceeded 8.9 Torr during normoxia and 18.8 Torr during hypoxia. Backward perfusion increased the total pressure gradient across the lung, mainly because of an increase in delta Pm. These results can be explained by a model in which the arterial and venous regions are represented by ohmic resistors and the middle region is represented by a Starling resistor in series and proximal to an ohmic resistor. In terms of this model, hypoxia exerted its major effects by increasing the critical pressure provided by the Starling resistor of the middle region and the ohmic resistance of the arterial region.
    Type of Medium: Online Resource
    ISSN: 8750-7587 , 1522-1601
    URL: Article
    DOI: 10.1152/jappl.1985.59.6.1891
    RVK:
    WA 15000
    RVK:
    XA 52094
    Language: English
    Publisher: American Physiological Society
    Publication Date: 1985
    detail.hit.zdb_id: 1404365-8
    SSG: 12
    SSG: 31
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 6
    Online Resource
    Online Resource
    Nature of Pulmonary Damage Produced by High Oxygen Pressures
    American Physiological Society ; 1956
    In:  Journal of Applied Physiology Vol. 9, No. 1 ( 1956-07), p. 1-4
    Details
    In: Journal of Applied Physiology, American Physiological Society, Vol. 9, No. 1 ( 1956-07), p. 1-4
    Type of Medium: Online Resource
    ISSN: 8750-7587 , 1522-1601
    URL: Article
    DOI: 10.1152/jappl.1956.9.1.1
    RVK:
    WA 15000
    RVK:
    XA 52094
    Language: English
    Publisher: American Physiological Society
    Publication Date: 1956
    detail.hit.zdb_id: 1404365-8
    SSG: 12
    SSG: 31
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 7
    Online Resource
    Online Resource
    Nature of sleep in young infants
    American Physiological Society ; 1962
    In:  Journal of Applied Physiology Vol. 17, No. 3 ( 1962-05-01), p. 543-546
    Details
    In: Journal of Applied Physiology, American Physiological Society, Vol. 17, No. 3 ( 1962-05-01), p. 543-546
    Abstract: Using criteria of ocular reactions, bodily activity, and respiration in 12 infants up to 6 months of age, four stages of the waking and the sleeping state have been distinguished: 1) deep sleep, as judged by closed eyes, virtual disappearance of bodily activity, regular respiration, and lowered frequency of breathing; 2) sleep with closed eyes, but greater bodily activity and irregularity of respiration; 3) light sleep, or the transitional state between sleep and waking as manifested by alternating open, closed, and half-open eyes, increased activity and frequency of breathing, and irregularity of respiration; 4) the waking state with open eyes, great bodily activity and respiratory frequency, and irregular respiration. This differentiation has enabled more accurate modification of the usually reported observations concerning the shortening of sleep in early life. It is not the duration of deep sleep which decreases, but rather the transitional state between sleep and waking. The waking state significantly lengthens with age. Note: (With the Technical Assistance of V. Lapáccaronková) Submitted on August 14, 1961
    Type of Medium: Online Resource
    ISSN: 8750-7587 , 1522-1601
    URL: Article
    DOI: 10.1152/jappl.1962.17.3.543
    RVK:
    WA 15000
    RVK:
    XA 52094
    Language: English
    Publisher: American Physiological Society
    Publication Date: 1962
    detail.hit.zdb_id: 1404365-8
    SSG: 12
    SSG: 31
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 8
    Online Resource
    Online Resource
    Nonpurinergic nature and efficacy of nonadrenergic bronchodilation
    American Physiological Society ; 1982
    In:  Journal of Applied Physiology Vol. 52, No. 3 ( 1982-03-01), p. 562-569
    Details
    In: Journal of Applied Physiology, American Physiological Society, Vol. 52, No. 3 ( 1982-03-01), p. 562-569
    Abstract: The nonadrenergic inhibition of airway smooth muscle was investigated in vivo in the anesthetized cat. We examined 1) the bronchodilatating nature of the selective purinergic agonists [adenosine (AD) and adenosine triphosphate (ATP)], 2) antagonistic nature of aminophylline and quinidine, and 3) the comparative efficacy of nonadrenergic and sympathetic inhibition in reversing bronchoconstriction induced with serotonin. Alterations in smooth muscle tone were studied via electrical stimulation of the vagus nerves and measurements of pulmonary resistance. We found that neither AD nor ATP, aerosolized or injected, altered the tonic bronchoconstriction. Dipyridamole, an AD reuptake inhibitor, did not alter the response to AD, ATP, or electrical stimulation. Both aminophylline and quinidine block nonadrenergic dilatation at high dose levels (69 and 29 mg/kg, respectively); further, both reputed antagonists impair cholinergic excitation. Nonadrenergic inhibition is equipotent to sympathetic inhibition in reversing bronchoconstriction; however, nonadrenergic inhibition is more prolonged (4.0 +/- 1.8 min). We conclude that probably neither ATP nor AD is the neurotransmitter for nonadrenergic bronchodilatation in the cat, and that nonadrenergic inhibition is both potent and long lasting.
    Type of Medium: Online Resource
    ISSN: 8750-7587 , 1522-1601
    URL: Article
    DOI: 10.1152/jappl.1982.52.3.562
    RVK:
    WA 15000
    RVK:
    XA 52094
    Language: English
    Publisher: American Physiological Society
    Publication Date: 1982
    detail.hit.zdb_id: 1404365-8
    SSG: 12
    SSG: 31
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 9
    Online Resource
    Online Resource
    Quantitative assessments of morphological and functional properties of biological trees based on their fractal nature
    American Physiological Society ; 2007
    In:  Journal of Applied Physiology Vol. 102, No. 6 ( 2007-06), p. 2315-2323
    Details
    In: Journal of Applied Physiology, American Physiological Society, Vol. 102, No. 6 ( 2007-06), p. 2315-2323
    Abstract: The branching systems in our body (vascular and bronchial trees) and those in the environment (plant trees and river systems) are characterized by a fractal nature: the self-similarity in the bifurcation pattern. They increase their branch density toward terminals according to a power function with the exponent called fractal dimension ( D). From a stochastic model based-on this feature, we formulated the fractal-based integrals to calculate such morphological parameters as aggregated branch length, surface area, and content volume for any given range of radius ( r). It was followed by the derivation of branch number and cross-sectional area, by virtue of the logarithmic sectioning of the r axis and of the branch radius-length relation also given by a power function of r with an exponent (α). These derivatives allowed us to quantify various hydrodynamic parameters of vascular and bronchial trees as fluid conduit systems, including the individual branch flow rate, mean flow velocity, wall shear rate and stress, internal pressure, and circumferential tension. The validity of these expressions was verified by comparing the outcomes with actual data measured in vivo in the vascular beds. From additional analyses of the terminal branch number, we found a simple equation relating the exponent ( m) of the empirical power law (Murray's so-called cube law) to the other exponents as ( m = D + α). Finally, allometric studies of mammalian vascular trees revealed uniform and scale-independent distributions of terminal arterioles in organs, which afforded an infarct index, reflecting the severity of tissue damage following arterial infarction.
    Type of Medium: Online Resource
    ISSN: 8750-7587 , 1522-1601
    URL: Article
    DOI: 10.1152/japplphysiol.00856.2006
    RVK:
    WA 15000
    RVK:
    XA 52094
    Language: English
    Publisher: American Physiological Society
    Publication Date: 2007
    detail.hit.zdb_id: 1404365-8
    SSG: 12
    SSG: 31
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 10
    Online Resource
    Online Resource
    Nature of vibration hyperventilation.
    American Physiological Society ; 1966
    In:  Journal of Applied Physiology Vol. 21, No. 2 ( 1966-03), p. 404-410
    Details
    In: Journal of Applied Physiology, American Physiological Society, Vol. 21, No. 2 ( 1966-03), p. 404-410
    Type of Medium: Online Resource
    ISSN: 8750-7587 , 1522-1601
    URL: Article
    DOI: 10.1152/jappl.1966.21.2.404
    RVK:
    WA 15000
    RVK:
    XA 52094
    Language: English
    Publisher: American Physiological Society
    Publication Date: 1966
    detail.hit.zdb_id: 1404365-8
    SSG: 12
    SSG: 31
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...