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  • 1
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    Planning operations before market launch for balancing time-to-market and risks in pharmaceutical supply chains (2014)
    Elsevier
    Details
    Publication Date: 2014-11-11
    Description: Publication date: Available online 4 November 2014 Source: International Journal of Production Economics Author(s): Klaus Reinholdt Nyhuus Hansen , Martin Grunow Shorter product life cycles and the resulting increase in new product introductions boost the importance of product launch operations. In the pharmaceutical sector, product launch operations are of particular importance, as companies seek to reduce time-to-market to better exploit patent protection. Large volumes of product need to be ready to fill the downstream supply chain immediately at market launch. Building up the required inventory is, however, connected to several risks. In addition to the risk associated with the lack of demand information for a new product, there are several risks unique to the pharmaceutical sector. After approval by central authorities such as the FDA or EMA, a new drug still needs to receive market authorization, which is in most cases granted by some local authorities - in Europe, for example, by more than 30 national and regional bodies. The duration of these different market authorization processes as well as their outcomes (e.g. price and reimbursement levels, requirements of label or leaflet changes) are highly uncertain. We develop a two-stage stochastic model to support market launch preparation decisions. It trades off the costs of accepting these risks, for example by risk packaging before authorization, against the lost revenue caused by risk-averse operations. The model is applied to a case based on an empirical study. Our approach results in significant savings compared to current practices. We hereby provide an example of how quantitative methodology can provide valuable decision support for product launch operations, even when complex regulatory affairs need to be considered.
    Print ISSN: 0925-5273
    Electronic ISSN: 1873-7579
    Topics: Technology , Economics
    Published by Elsevier
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    PAPER CURRENT
  • 2
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    Sustainable Blue Economy - Transformation, Value and the Potential of Marine Ecosystems (2022)
    FERI Cognitive Finance Institute
    Details
    Publication Date: 2023-07-24
    Description: "We have to make sure that as we grow the blue economy, it accelerates in a regenerative way. Moving to a sustainable blue economy would benefit food security, human health, underdeveloped communities - and of course, the environment." Alexandra Cousteau, President and Co-Founder Oceans 2050
    Type: Report , NonPeerReviewed
    Format: text
    Format: text
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    OceanRep: Report - other report
  • 3
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    Promoting Geoethics in Society: A New Challenge for Geoscientists (2015)
    American Geosciences Institute (AGI)
    Details
    Publication Date: 2017-04-04
    Description: The Geoscience community is called to play an important role in society: helping in the defense against natural risks, orienting on global issues like climate change, looking for new ways to source natural resources from a sustainable perspective, building a knowledgeable society and help to improve the living conditions of human life especially in low income countries. This implies geoscientists are more aware of their social responsibility and capable of working by the principles of integrity, honesty with respect for land, water and air...
    Description: Published
    Description: 42-44
    Description: 3T. Pericolosità sismica e contributo alla definizione del rischio
    Description: 4V. Vulcani e ambiente
    Description: 4A. Clima e Oceani
    Description: 5A. Energia e georisorse
    Description: N/A or not JCR
    Description: restricted
    Keywords: geoethics ; IAPG ; Society ; Geoscientists ; Earth Sciences ; 05. General::05.03. Educational, History of Science, Public Issues::05.03.99. General or miscellaneous ; 05. General::05.09. Miscellaneous::05.09.99. General or miscellaneous
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: article
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    PAPER (OA)
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