In:
American Journal of Physiology-Legacy Content, American Physiological Society, Vol. 187, No. 1 ( 1956-09-30), p. 113-121
Abstract:
Thrombin formation has been shown to be inhibited by oxidized glutathione and other sulfhydryl-oxidizing agents. This effect is observed with purified bovine prothrombin and with prothrombin as present in human plasma. It is different in nature from a similar inhibition brought about by sulfhydryl-containing (reducing) substances. Experiments with purified clotting factors and a variety of plasma and serum preparations have been carried out in order to elucidate the nature of the inhibition produced by SH-oxidizing substances. The results obtained indicate that thrombin formation is inhibited by these reagents as a result of their reaction with Ac-globulin sulfhydryl groups leading to partial or complete inactivation of this accelerator.
Type of Medium:
Online Resource
ISSN:
0002-9513
DOI:
10.1152/ajplegacy.1956.187.1.113
Language:
English
Publisher:
American Physiological Society
Publication Date:
1956
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1477287-5
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1477308-9
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1477297-8
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1477300-4
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1477329-6
SSG:
12
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