In:
American Journal of Physiology-Legacy Content, American Physiological Society, Vol. 188, No. 2 ( 1957-01-31), p. 409-414
Abstract:
Serum protein, lipoprotein and glycoprotein patterns have been studied in irradiated dogs, using paper electrophoresis techniques. Alpha-1 globulin lipid decreases in the terminal stages following fatal doses of x-radiation, this change reflecting a loss of lipoprotein. Considerably increased levels of alpha-2-3 globulin lipid and polysaccharide in extremely sick or dying dogs results from increased concentrations of lipoproteins and glycoproteins. Decreased alpha-4 globulin polysaccharide is a function of a loss of glycoprotein, while slight increases of beta globulin lipid reflect gains of beta lipoproteins. The loss of alpha-4 and gain of alpha-3 glycoproteins, have been found as early as 10 days prior to irradiation death, and in the absence of lipoprotein or body temperature abnormalities. In dogs surviving irradiation doses near the ld 50 , transitory lipoprotein changes are slight, while glycoprotein derangements are more pronounced. Mechanisms underlying these various changes are discussed.
Type of Medium:
Online Resource
ISSN:
0002-9513
DOI:
10.1152/ajplegacy.1957.188.2.409
Language:
English
Publisher:
American Physiological Society
Publication Date:
1957
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1477334-X
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1477297-8
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1477329-6
SSG:
12
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