In:
Acta Medica Scandinavica, Wiley, Vol. 187, No. 1-6 ( 1970-01-12), p. 257-265
Abstract:
Abstract. A study of the distribution and morphology of Howell‐Jolly bodies in blood, bone marrow and spleen aspirates from patients with and without functioning spleen led to the conclusion that most bodies so labelled are not intracellular remnants of the normoblast nuclei. They are in most cases situated on the outside of the erythrocyte membrane and to be regarded as degradation products of nuclei, digested by bone marrow phagocytes and released from these cells at a certain stage of degradation. They are normally removed by the spleen; in the absence of the spleen they may remain for some time in circulating blood with a tendency to adhere to red cells.
Type of Medium:
Online Resource
ISSN:
0001-6101
DOI:
10.1111/joim.1970.187.issue-1-6
DOI:
10.1111/j.0954-6820.1970.tb02941.x
Language:
English
Publisher:
Wiley
Publication Date:
1970
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