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  • American Association for the Advancement of Science (AAAS)  (403)
  • English  (403)
  • 1
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    More Squabbling Over Unbelievable Result : Nature's publication of the investigation of an unbelievable experiment has triggered as much debate on the journal's conduct as on the truth or falseness of the results
    American Association for the Advancement of Science (AAAS) ; 1988
    In:  Science Vol. 241, No. 4866 ( 1988-08-05), p. 658-658
    Details
    In: Science, American Association for the Advancement of Science (AAAS), Vol. 241, No. 4866 ( 1988-08-05), p. 658-658
    Type of Medium: Online Resource
    ISSN: 0036-8075 , 1095-9203
    URL: Article
    DOI: 10.1126/science.3399898
    RVK:
    TA 1000
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    WA 15000
    Language: English
    Publisher: American Association for the Advancement of Science (AAAS)
    Publication Date: 1988
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  • 2
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    Big ideas for small humans Tree of Wonder The Many Marvelous Lives of a Rainforest Tree Kate Messner, illustrated by Simona Mulazzani Chronicle, 2015. 30 pp. When Whales Cross the Sea The Gray Whale Migration Sharon Katz Cooper, illustrated by Tom Leonard Picture Window, 2015. 24 pp. A Chicken Followed Me Home Questions and Answers About a Familiar Fowl Robin Page Beach Lane, 2015. 30 pp. High Tide for Horseshoe Crabs Lisa Kahn Schnell, illustrated by Alan Marks Charlesbridge, 2015. 38 pp. Egg Nature's Perfect Package Steve Jenkins, Robin Page HMH Books for Young Readers, 2015. 32 pp. The Octopus Scientists Exploring the Mind of a Mollusk Sy Montgomery, photography by Keith Ellenbogen HMH Books for Young Readers, 2015. 80 pp. Untamed The Wild Life of Jane Goodall Anita Silvey National Geographic Children's Books, 2015. 96 pp. Migration Nation Animals on the Go from Coast to Coast Joanne O'Sullivan Imagine, 2015. 96 pp. Remaking the John The Invention and Reinvention of the Toilet Francesca Davis DiPiazza Twenty-First Century, 2015. 64 pp. Trash Talk Moving Toward a Zero-Waste World Michelle Mulder Orca, 2015. 48 pp. Kirby's Journal Backyard Butterfly Magic Charlotte Caldwell University of South Carolina Press, 2015. 59 pp. A Kid's Guide to Keeping Chickens Best Breeds, Creating a Home, Care and Handling, Outdoor Fun, Crafts and Treats Melissa Caughey Storey, 2015. 150 pp. Experiment with What a Plant Needs to Grow Nadia Higgins Lerner, 2015. 32 pp. Birdology 30 Activities and Observations for Exploring the World of Birds Monica Russo, photography by Kevin Byron Chicago Review Press, 2015. 120 pp. Inventions That Could Have Saved the World …But Didn't Joe Rhatigan, illustrated by Anthony Owsley Imagine, 2015. 80 pp. How to Clone a Mammoth The Science of De-Extinction Beth Shapiro Princeton University Press, 2015. 248 pp. The Boy Who Played with Fusion Extreme Science, Extreme Parenting, and How to Make a Star Tom Clynes Eamon Dolan/Houghton Mifflin Harcourt, 2015. 327 pp. The Soul of an Octopus A Surprising Exploration into the Wonder of Consciousness Sy Montgomery Atria, 2015. 275 pp. The Triumph of Seeds How Grains, Nuts, Kernels, Pulses, and Pips Conquered the Plant Kingdom and Shaped Human History Thor Hanson Basic, 2015. 303 pp.
    American Association for the Advancement of Science (AAAS) ; 2015
    In:  Science Vol. 350, No. 6265 ( 2015-12-04), p. 1152-1159
    Details
    In: Science, American Association for the Advancement of Science (AAAS), Vol. 350, No. 6265 ( 2015-12-04), p. 1152-1159
    Abstract: Would you be willing to move to Tanzania? Do you have the materials necessary to achieve nuclear fusion lying around the house? Are you prepared to build a chicken coop in the backyard? If you answered "yes" to any of these questions, you are well on your way to accommodating some of the requests that this year's finalists for the Science Books and Films (SB & F) Prizes for Excellence in Science Books are bound to elicit. If not, no need to worry: The books are just as enjoyable to peruse without, say, booking a trip to the International Space Station. The annual SB & F competition, sponsored by AAAS and funded by Subaru, is intended to promote science literacy and to encourage the writing and publishing of high-quality science books for children and young adults. The shortlist below was compiled by a panel of scientists, librarians, and science literary experts from 214 submissions, published between September 2014 and September 2015. Winners in each category will be announced at the upcoming AAAS Annual Meeting in Washington, D.C. Can you guess which ones will take home the prize?
    Type of Medium: Online Resource
    ISSN: 0036-8075 , 1095-9203
    URL: Article
    DOI: 10.1126/science.aad8617
    RVK:
    TA 1000
    RVK:
    WA 15000
    Language: English
    Publisher: American Association for the Advancement of Science (AAAS)
    Publication Date: 2015
    detail.hit.zdb_id: 128410-1
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  • 3
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    Nature journals ink open-access deal
    American Association for the Advancement of Science (AAAS) ; 2020
    In:  Science Vol. 370, No. 6515 ( 2020-10-23), p. 391-391
    Details
    In: Science, American Association for the Advancement of Science (AAAS), Vol. 370, No. 6515 ( 2020-10-23), p. 391-391
    Abstract: A prominent publisher of selective subscription journals has stepped up its commitment to open access and bringing down paywalls. The Nature family of journals announced this week it has struck a deal that will allow scientists at research institutions across Germany to publish papers in Nature and its 54 sister journals that are immediately free to read. Starting in January 2021, institutions can pay an annual fee that allows their scientists to publish an unlimited number of research articles in the journals that will be free to all readers. The fee will also include access to read other types of Nature content. The fee each institution pays will be based in part on Nature's calculation that it will cost €9500 ($11,200) to publish each open-access paper.
    Type of Medium: Online Resource
    ISSN: 0036-8075 , 1095-9203
    URL: Article
    DOI: 10.1126/science.370.6515.391-a
    RVK:
    TA 1000
    RVK:
    WA 15000
    Language: English
    Publisher: American Association for the Advancement of Science (AAAS)
    Publication Date: 2020
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  • 4
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    Sensory Overload
    American Association for the Advancement of Science (AAAS) ; 2001
    In:  Science's STKE Vol. 2001, No. 100 ( 2001-09-18)
    Details
    In: Science's STKE, American Association for the Advancement of Science (AAAS), Vol. 2001, No. 100 ( 2001-09-18)
    Abstract: If you are interested in signal transduction underlying sensory perception, then you won't want to miss this week's Nature . Five reviews cover signaling in the Drosophila visual system by Hardie and Raghu, mechanosensory transduction (touch) by Gillespie and Walker, pain perception by Julius and Basbaum, olfaction by Firestein, and taste by Lindemann. In addition to the articles covering the cellular and molecular basis of sensory perception, Bayley and Cremer describe the application of sensory research to the development of biosensors. R. C. Hardie, P. Raghu, Visual transduction in Drosophila . Nature 413 , 186-193 (2001). [Online Journal] P. G. Gillespie, R. G. Walker, Molecular basis of mechanosensory transduction. Nature 413 , 194-202 (2001). [Online Journal] D. Julius, A. I Basbaum, Molecular mechanisms of nociception. Nature 413 , 203-210 (2001). [Online Journal] S. Firestein, How the olfactory system makes sense of scents. Nature 413 , 211-218 (2001). [Online Journal] B. Lindemann, Receptors and transduction in taste. Nature 413 , 219-225 (2001). [Online Journal] H. Bayley, P. S. Cremer, Stochastic sensors inspired by biology. Nature 413 , 226-230 (2001). [Online Journal]
    Type of Medium: Online Resource
    ISSN: 1525-8882
    URL: Article
    DOI: 10.1126/stke.2001.100.tw336
    Language: English
    Publisher: American Association for the Advancement of Science (AAAS)
    Publication Date: 2001
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  • 5
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    Cardiac Function
    American Association for the Advancement of Science (AAAS) ; 2002
    In:  Science's STKE Vol. 2002, No. 115 ( 2002-01-15)
    Details
    In: Science's STKE, American Association for the Advancement of Science (AAAS), Vol. 2002, No. 115 ( 2002-01-15)
    Abstract: This week's issue of Nature contains a large section devoted to cardiology. Of those articles, several are of a molecular nature, and may be of interest to STKE readers. Bers reviews the mechanisms that govern the transport of ions across membranes leading to the highly orchestrated contraction of the heart, whereas Marbán reviews how mutations and chronic modifications of various ion channels can lead to cardiac arrhythmias and heart failure. Rockman et al. review the G protein-coupled receptors known to be involved in cardiac function. D. M. Bers, Cardiac excitation-contraction coupling. Nature 415 , 198-205 (2002). [Online Journal] E. Marbán, Cardiac channelopathies. Nature 415 , 213-218 (2002). [Online Journal] H. A. Rockman, W. J. Koch, R. J. Lefkowitz, Seven-transmembrane-spanning receptors and heart function. Nature 415 , 206-212 (2002). [Online Journal]
    Type of Medium: Online Resource
    ISSN: 1525-8882
    URL: Article
    DOI: 10.1126/stke.2002.115.tw23
    Language: English
    Publisher: American Association for the Advancement of Science (AAAS)
    Publication Date: 2002
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  • 6
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    Apoptosis Times 6
    American Association for the Advancement of Science (AAAS) ; 2000
    In:  Science's STKE Vol. 2000, No. 54 ( 2000-10-17)
    Details
    In: Science's STKE, American Association for the Advancement of Science (AAAS), Vol. 2000, No. 54 ( 2000-10-17)
    Abstract: Six reviews on apoptosis cover everything from the biochemistry of the apoptotic machinery to the physiological roles for apoptosis and pathologies associated with apoptotic mechanisms. Hengartner addresses the biochemistry of the apoptotic mechanism and the pathways that activate apoptosis. Rich, Allen, and Wyllie discuss how DNA damage is sensed and signals the apoptotic pathway and how the cell cycle checkpoints provide opportunities for cells to evade apoptosis by repairing the damage. Two articles cover apoptosis and the immune system: Savill and Fadok focus on mechanisms for the clearance of apoptotic cells by macrophages and how this process regulates immune responses; Krammer focuses on the role of CD95-mediated apoptosis in T cell and B cell development and during immune responses. Meier, Finch, and Evan review the contributions based on studies of nematode, fruitfly, and mouse to understanding the importance of apoptosis during development. Finally, Yuan and Yankner discuss the signaling pathways implicated in regulating apoptosis in the nervous system. Special attention is paid to the role apoptosis may play in several human diseases, including Alzheimer's disease, Huntington's disease, and Parkinson's disease. Hengartner, M.O. (2000) The biochemistry of apoptosis. Nature 407 : 770-776. [Online Journal] Rich, T., Allen, R.L., and Wyllie, A.H. (2000) Defying death after DNA damage. Nature 407 : 777-783. [Online Journal] Savill, J., and Fadok, V. (2000) Corpse clearance defines the meaning of cell death. Nature 407 : 784-788. [Online Journal] Krammer, P.H. (2000) CD95's deadly mission in the immune system. Nature 407 : 789-795. [Online Journal] Meier, P., Finch, A., and Even, G. (200) Apoptosis in development. Nature 407 : 796-801. [Online Journal] Yuan, J., and Yankner, B.A. (2000) Apoptosis in the nervous system. Nature 407 : 802-809. [Online Journal]
    Type of Medium: Online Resource
    ISSN: 1525-8882
    URL: Article
    DOI: 10.1126/stke.2000.54.tw9
    Language: English
    Publisher: American Association for the Advancement of Science (AAAS)
    Publication Date: 2000
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  • 7
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    Insights into Cancer
    American Association for the Advancement of Science (AAAS) ; 2001
    In:  Science's STKE Vol. 2001, No. 83 ( 2001-05-22)
    Details
    In: Science's STKE, American Association for the Advancement of Science (AAAS), Vol. 2001, No. 83 ( 2001-05-22)
    Abstract: Understanding the extracellular and intracellular signals that control normal cell growth and proliferation has been central to deciphering the underlying causes of human cancers. Although cells strive to coordinate and balance a plethora of signaling cascades, the slightest perturbation can result in deregulation of critical cellular processes. A collection of articles in Nature that highlight recent progress in the control of the cell division cycle and apoptosis, protein kinase activation, and cell proliferation during embryonic development attests to how future development of effective therapeutics requires an integrated understanding of how deregulation of cell proliferation leads to tumorigenesis. G. I. Evan, K. H. Vousden, Proliferation, cell cycle and apoptosis in cancer, Nature 411 , 342-348 (2001). [Online Journal] J. Taipale, P. A. Beachy, The hedgehog and Wnt signalling pathways in cancer, Nature 411 , 349-354 (2001). [Online Journal] P. Blume-Jensen, T. Hunter, Oncogenic kinase signalling, Nature 411 , 355-365 (2001). [Online Journal]
    Type of Medium: Online Resource
    ISSN: 1525-8882
    URL: Article
    DOI: 10.1126/stke.2001.83.tw2
    Language: English
    Publisher: American Association for the Advancement of Science (AAAS)
    Publication Date: 2001
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  • 8
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    An Inhibitor of Nerve Regrowth Revealed
    American Association for the Advancement of Science (AAAS) ; 2000
    In:  Science's STKE Vol. 2000, No. 17 ( 2000-02)
    Details
    In: Science's STKE, American Association for the Advancement of Science (AAAS), Vol. 2000, No. 17 ( 2000-02)
    Abstract: Three groups report the cloning and characterization of a myelin protein, Nogo, which inhibits the outgrowth of central nervous system neurons. Goldberg and Barres highlight these reports in a Nature news and views article. Nogo belongs to the Reticulon family of proteins, which have two putative transmembrane domains and a COOH-terminal endoplasmic reticulum retention signal. All three groups identified three transcripts with Nogo-A being the longest and Nogo-B and Nogo-C encoding variants with smaller NH 2 -terminal domains. Chen et al . identified rat Nogos and demonstrated that Nogo-A was restricted in expression to nervous tissue. Prinjha et al . and GrandPré et al . both identified human Nogos. Each group used different approaches to identify the regions responsible for inhibiting neurite outgrowth and reported different regions of Nogo-A as having the inhibitory activity. All of the regions identified would not be displayed extracellularly if Nogo-A had only the two predicted transmembrane domains raising the issue of the topology of Nogo proteins. Nogo-A was found to be predominantly intracellular raising the question of how Nogo proteins act as myelin-associated inhibitors of nerve regeneration. Chen, M.S., Huber, A.B., van der Haar, M.E., Frank, M., Schnell, L., Spillmann, A.A., Christ, F., and Schwab, M.E. (2000) Nogo-A is a myelin-associated neurite outgrowth inhibitor and an antigen for the monoclonal IN-1. Nature 403: 434-438. [Online Journal] Prinjha, R., Moore, S.E., Vinson, M., Blake, S., Morrow, R., Christie, G., Michalovish, D., Simmons, D.L., and Walsh, F.S. (2000) Inhibitor of neurite outgrowth in humans. Nature 403: 383-384. [Online Journal] GrandPré, T., Nakamura, F., Vartanian, T., and Strittmatter, S.M. (2000) Identification of the Nogo inhibitor of axon regeneration as a Reticulon protein. Nature 403: 439-444. [Online Journal] Goldberg, J.L. and Barres, B.A. (2000) Nogo in nerve regeneration. Nature 403: 369-370. [Online Journal]
    Type of Medium: Online Resource
    ISSN: 1525-8882
    URL: Article
    DOI: 10.1126/stke.2000.17.tw5
    Language: English
    Publisher: American Association for the Advancement of Science (AAAS)
    Publication Date: 2000
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  • 9
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    Stimulatory Effects of ICOS
    American Association for the Advancement of Science (AAAS) ; 2001
    In:  Science's STKE Vol. 2001, No. 64 ( 2001-01-09)
    Details
    In: Science's STKE, American Association for the Advancement of Science (AAAS), Vol. 2001, No. 64 ( 2001-01-09)
    Abstract: T cell activation is thought to require two events: engagement of the T cell receptor with antigen that is presented on the surface of an antigen-presenting cell (APC), and costimulatory signals that involve engagement of other molecule pairs between the T cell and the APC. One such costimulatory pair is the inducible costimulatory molecule (ICOS) present on T cells and its ligand B7HRP-1. Three groups have analyzed the contribution of this interaction to immune function in vivo by generating ICOS-null mice. ICOS-deficient mice exhibited defects in T cell activation and proliferation, failing to produce critical cytokines including interleukins 2 and 4. The absence of ICOS also impaired the ability of T cells to direct the appropriate humoral response to antigens, indicating its importance in promoting T cell-B cell collaboration. The findings are summarized by Schwartz, who suggests that this costimulatory molecule has important implications in allergic reactions and the inflammatory response in humans. Dong, C., Juedes, A.E., Temann, U.-A., Shresta, S., Allison, J.P., Ruddle, N.H., and Flavell, R.A. (2000) ICOS co-stimulatory receptor is essential for T-cell activation and function. Nature 409 : 97-101. [Online Journal] McAdam, A.J., Greenwald, R.J., Levin, M.A., Chernova, T., Malenkovich, N., Ling, V., Freeman, G.J., and Sharpe, A.H. (2000) ICOS is critical for CD40-mediated antibody class switching. Nature 409 : 102-105. [Online Journal] Tafuri, A., Shahinian, A., Bladt, F., Yoshinaga, S.K., Jordana, M., Wakeham, A., Boucher, L.-M., Bouchard, D., Chan, V.S.F., Duncan, G., Odermatt, B., Ho, A., Itie, A., Horan, T., Whoriskey, J.S., Pawson, T., Penninger, J.M., Ohashi, P.S., and Mak, T.W. (2000) ICOS is essential for effective T-helper-cell responses. Nature 409 : 105-109. [Online Journal] Schwartz, R.H. (2000) It takes more than two to tango. Nature 409 : 31-32. [Online Journal]
    Type of Medium: Online Resource
    ISSN: 1525-8882
    URL: Article
    DOI: 10.1126/stke.2001.64.tw9
    Language: English
    Publisher: American Association for the Advancement of Science (AAAS)
    Publication Date: 2001
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  • 10
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    Sugar-coating Notch
    American Association for the Advancement of Science (AAAS) ; 2000
    In:  Science's STKE Vol. 2000, No. 43 ( 2000-08)
    Details
    In: Science's STKE, American Association for the Advancement of Science (AAAS), Vol. 2000, No. 43 ( 2000-08)
    Abstract: Notch is a transmembrane receptor for the transmembrane ligands Delta and Jagged (also known as Serrate). Signaling by Notch is important for establishing boundaries during development (see accompanying article by Fortini). Fringe modifies Notch signaling when expressed in Notch-expressing cells. Two groups, Brückner et al . and Moloney et al ., show that Fringe is a glycosyltransferase that catalyzes the elongation of O -linked fucose residues on the epidermal growth factor repeats of the Notch receptor. Brückner et al . show that coexpression of Fringe and Notch enhances the interaction between Notch and Delta and that the glycosyltransferase activity of Fringe is essential for this activity. Moloney et al . show that when Notch is modified by Fringe, activation of Notch by Jagged1 is inhibited. Thus, carbohydrate modification of the Notch receptor fine-tunes the cellular responsiveness to Notch ligands, allowing the establishment of discrete boundaries of Notch signaling. Carbohydrate modification represents a novel mechanism of regulating receptor-ligand interactions. Fortini, M.E. (2000) Fringe benefits to carbohydrates. Nature 406 : 357-358. [Online Journal] Brückner, K., Perez, L., Clausen, H., and Cohen, S. (2000) Glycosyltransferase activity of Fringe modulates Notch-Delta interactions. Nature 406 : 411-415. [Online Journal] Moloney, D.J., Panin, V.M., Johnston, S.H., Chen, J., Shao, L., Wilson, R., Wang, Y., Stanley, P., Irvine, K.D., Haltiwanger, R.S., and Vogt, T.F. (2000) Fringe is a glycosyltransferase that modifies Notch. Nature 406 : 369-375. [Online Journal]
    Type of Medium: Online Resource
    ISSN: 1525-8882
    URL: Article
    DOI: 10.1126/stke.2000.43.tw1
    Language: English
    Publisher: American Association for the Advancement of Science (AAAS)
    Publication Date: 2000
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