Abstract
The interaction of the antibiotic tetracycline with a few metal ions, esp. Cu(II), in different so l vents has been investigated by means of IR, ESR, and UV /VIS spectroscopy. It could be shown that the site of complexation depends on the solvent used. In DMSO the interaction occurs mainly via the A ring. In water (pH = 5.7) and octanol, the A chromophore as well as the BCD entity of the molecule are involved in complexation. If the tetracycline concentration exceeds the Cu(II) concentration, a 2 : 1 (antibiotic : Cu(II)) complex seems to be formed, at least in DMSO.
Received: 1979-6-25
Published Online: 2014-6-2
Published in Print: 1979-12-1
© 1946 – 2014: Verlag der Zeitschrift für Naturforschung
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