Discovery of a Novel Compound with Anti-Venezuelan Equine Encephalitis Virus Activity That Targets the Nonstructural Protein 2
Figure 5
Effect of CID15997213 on survival of VEEV TC-83 infected mice.
Six groups of ten C3H/HeN mice were used to assess antiviral activity in vivo; Group 1-Vehicle control; Group 2-VEEV only; Group 3- VEEV and 2 mg/kg/day CID15997213; Group 4- VEEV and 10 mg/kg/day CID15997213; Group 5- VEEV and 50 mg/kg/day CID15997213; Group 6- VEEV and 200 mg/kg/day CID15997213. Vehicle or CID15997213 were administered by i.p. four hours prior to mock or i.n. infection of VEEV TC-83. Treatments continued for from D0 though D5. Survival of mice in each group in plotted by time. Each group was compared to Group 3 for measurement of the p-value using the Mantel-Cox test. Analyses of each P value generated by the Mantel-Cox test were evaluated by comparison to a Bonferroni corrected threshold of 0.0125 (p = 0.05) to measure any potential significant differences between groups.