Effect of remote ischemic preconditioning on hemostasis and fibrinolysis in head and neck cancer surgery: A randomized controlled trial
Fig 3
Fibrin clot lysis assay and fibrinolysis biomarkers.
Data are shown as mean ± SD or median with IQR. Lines indicate common reference intervals for healthy men and women from our laboratory if available. Reference intervals for tPA and PAI-1 were provided by the manufacturer. P-values represent the multivariate repeated measures ANOVA. Mixed-model was used for fibrin clot lysis data. Missing data: Fibrin clot lysis produced flat curves in 18 samples obtained pre-intervention (8 RIPC, 10 sham), 5 samples obtained 3 h post-intervention (3 RIPC, 2 sham), and 14 samples obtained on the first postoperative day (7 RIPC, 7 sham). Fibrin clot lysis curves did not lyse in 4 samples obtained 3 h post-intervention (2 RIPC, 2 sham) and 6 samples obtained 6 h post-intervention (3 RIPC, 3 sham). Abbreviations: PAI-1: plasminogen activator inhibitor-1, RIPC: remote ischemic preconditioning, TAFI: thrombin activatable fibrinolysis inhibitor, tPA: tissue-type plasminogen activator.