Humanization and Characterization of an Anti-Human TNF-α Murine Monoclonal Antibody
Figure 7
Assessment of scores in collagen antibody-induced arthritic mice treated with h357 IgG and phosphate buffered saline.
At the time of disease onset (day 0), mice were given by intra-peritoneal injection of h357 IgG (50 µg) or 100 µl of phosphate buffered saline (non-treatment) once-daily for 9 consecutive days. The arthritis scores were compared between non-treated (n = 4) and h357 IgG (n = 5) treated groups during the course of treatment. Scoring results were expressed as mean ± standard deviation (SD). When mice were treated with h357 IgG, the rate of arthritis development was significantly reduced (P<0.05).