Hippocampal Atrophy as a Quantitative Trait in a Genome-Wide Association Study Identifying Novel Susceptibility Genes for Alzheimer's Disease
Figure 1
Manhattan plot of the quantitative trait genome wide association analysis.
Manhattan plot of the p-values (-Log10(Observed p-value)) from the QT (right hippocampus) genome-wide association analysis. The spacing between the SNPs does not reflect the actual distances between SNPs in the genome. Each color identifies an autosomal chromosome (from chromosome 1 to chromosome 22). The horizontal lines display the cutoffs for 3 significance levels: green line for mild significance (10−3<p<10−5), blue line for high significance (10−5<p<10−6) and red line for genome-wide significance level (p<10−6). Different symbols reflect the function of the SNPs as detailed here: “▴” intronic, “▪” 3′UTR or downstream region, “+” 5′UTR or upstream region, “⊠” synonymous coding, “░” non-synonymous coding, “•” intergenic.