Sodium-bile acid co-transporter is crucial for survival of a carcinogenic liver fluke Clonorchis sinensis in the bile
Fig 9
CsSBAT inhibition with polyacrylic acid–tetradeoxycholic acid conjugate (PATD) and bile acid accumulation.
(A) Confocal micrographs on the lateral region of intestine bifurcation in the Clonorchis sinensis adults. Scale bar = 80 μm. (B) Inhibitory effect of PATD on CsSBAT presented as fluorescence intensity of tauro-nor-THCA-24-DBD accumulated in the mesenchymal tissue. Tauro-nor-THCA-24-DBD concentration, 25 μM; PATD concentration, 400 μg/mL. Bar represents mean ± standard error. ***p < 0.001; NS, not significant.