Department of Internal Medicine, Tane General Hospital
Department of Internal Medicine, Tane General Hospital
Department of Internal Medicine, Tane General Hospital
Department of Internal Medicine, Tane General Hospital
Department of Internal Medicine, Tane General Hospital
Department of Internal Medicine, Tane General Hospital
Department of Internal Medicine, Tane General Hospital
The Second Departmet of Internal Medicine, School of Medicine, Hokkaido University and Related Hospital
The Second Departmet of Internal Medicine, School of Medicine, Hokkaido University and Related Hospital
Department of Respiratory Disease, Sapporo Hospital of Japanese National Railway
Department of Respiratory Disease, Sapporo Hospital of Japanese National Railway
Department of Respiratory Disease, Sapporo Hospital of Japanese National Railway
The Third Department of Internal Medicine, Hirosaki University, School of Medicine and Related Hospital
The Third Department of Internal Medicine, Hirosaki University, School of Medicine and Related Hospital
The Third Department of Internal Medicine, Hirosaki University, School of Medicine and Related Hospital
The Third Department of Internal Medicine, Hirosaki University, School of Medicine and Related Hospital
The Third Department of Internal Medicine, Hirosaki University, School of Medicine and Related Hospital
The Third Department of Internal Medicine, Hirosaki University, School of Medicine and Related Hospital
The Third Department of Internal Medicine, Hirosaki University, School of Medicine and Related Hospital
The Third Department of Internal Medicine, Hirosaki University, School of Medicine and Related Hospital
The Third Department of Internal Medicine, Hirosaki University, School of Medicine and Related Hospital
The Third Department of Internal Medicine, Hirosaki University, School of Medicine and Related Hospital
The First Department of Internal Medicine, Tohoku University, School of Medicine
The First Department of Internal Medicine, Tohoku University, School of Medicine
Department of Internal Medicine, The Research Institute for Chest Diseases and Cancer, Tohoku University and Related Hospital
Department of Internal Medicine, The Research Institute for Chest Diseases and Cancer, Tohoku University and Related Hospital
Department of Internal Medicine, The Research Institute for Chest Diseases and Cancer, Tohoku University and Related Hospital
Department of Internal Medicine, The Research Institute for Chest Diseases and Cancer, Tohoku University and Related Hospital
Department of Internal Medicine, The Research Institute for Chest Diseases and Cancer, Tohoku University and Related Hospital
Department of Respiratory Disease, Iwaki Kyoritsu General Hospital
Department of Internal Medicine, Kasumigaura National Hospital
Department of Internal Medicine, Kasumigaura National Hospital
Department of Internal Medicine, Kasumigaura National Hospital
Department of Internal Medicine, Kasumigaura National Hospital
The Second Department of Internal Medicine, Niigata University, School of Medicine and Related Hospital
The Second Department of Internal Medicine, Niigata University, School of Medicine and Related Hospital
The Second Department of Internal Medicine, Niigata University, School of Medicine and Related Hospital
The Second Department of Internal Medicine, Niigata University, School of Medicine and Related Hospital
Department of Internal Medicine, Nagaoka Red Cross Hospital
Department of Internal Medicine, Shinrakuen Hospital
Department of Internal Medicine, Shinrakuen Hospital
Department of Internal Medicine, Shinrakuen Hospital
The Second Department of Internal Medicine, The Jikei University, School of Medicine
The Second Department of Internal Medicine, The Jikei University, School of Medicine
The Second Department of Internal Medicine, The Jikei University, School of Medicine
The Second Department of Internal Medicine, The Jikei University, School of Medicine
Department of Internal Medicine, Juntendo University, School of Medicine
Department of Internal Medicine, Juntendo University, School of Medicine
The First Department of Internal Medicine, Kyorin University, School of Medicine
The First Department of Internal Medicine, Kyorin University, School of Medicine
The First Department of Internal Medicine, Kyorin University, School of Medicine
Department of Internal Medicine, Tokyo Koseinenkin Hospital
Department of Internal Medicine, Tokyo Koseinenkin Hospital
Department of Internal Medicine, Tokyo Koseinenkin Hospital
Department of Chest Medicine, National Medical Center Hospital
Department of Chest Medicine, National Medical Center Hospital
Department of Chest Medicine, National Medical Center Hospital
Department of Chest Medicine, National Medical Center Hospital
Department of Respiratory Disease, Toranomon Hospital
Department of Respiratory Disease, Toranomon Hospital
Department of Respiratory Disease, Toranomon Hospital
Department of Respiratory Disease, Toranomon Hospital
Department of Respiratory Disease, Toranomon Hospital
Department of Respiratory Disease, Toranomon Hospital
Department of Internal Medicine, Tokyo Kyosai Hospital
Department of Internal Medicine, Tokyo Kyosai Hospital
Department of Internal Medicine, Tokyo Kyosai Hospital
Department of Internal Medicine, Tokyo Metropolitan Geriatric Hospital
Department of Internal Medicine, Tokyo Metropolitan Geriatric Hospital
Department of Internal Medicine, Tokyo Denryoku Hospital
Department of Internal Medicine, Tokyo Denryoku Hospital
Department of Internal Medicine, Kawasaki Municipal Hospital
Department of Internal Medicine, Kawasaki Municipal Hospital
Department of Internal Medicine, Kawasaki Municipal Hospital
The First Department of Internal Medicine, Yokohama City University, School of Medicine
The First Department of Internal Medicine, Yokohama City University, School of Medicine
The First Department of Internal Medicine, Yokohama City University, School of Medicine
The First Department of Internal Medicine, Yokohama City University, School of Medicine
The First Department of Internal Medicine, Yokohama City University, School of Medicine
The First Department of Internal Medicine, Yokohama City University, School of Medicine
Department of Internal Medicine, Yokohama Teishin Hospital
Department of Respiratory Disease, Kanagawa Prefectural Nagahama Hospital
Department of Respiratory Disease, Kanagawa Prefectural Nagahama Hospital
Department of Respiratory Disease, Kanagawa Prefectural Nagahama Hospital
Department of Respiratory Disease, Kanagawa Prefectural Nagahama Hospital
Department of Respiratory Disease, Kanagawa Prefectural Nagahama Hospital
Department of Respiratory Disease, Kanagawa Prefectural Nagahama Hospital
Department of Respiratory Disease, Kanagawa Prefectural Nagahama Hospital
The First Department of Internal Medicine, Nagoya University, School of Medicine and Related Hospitals
The First Department of Internal Medicine, Nagoya University, School of Medicine and Related Hospitals
The First Department of Internal Medicine, Nagoya University, School of Medicine and Related Hospitals
The First Department of Internal Medicine, Nagoya University, School of Medicine and Related Hospitals
The First Department of Internal Medicine, Nagoya University, School of Medicine and Related Hospitals
The First Department of Internal Medicine, Nagoya University, School of Medicine and Related Hospitals
The First Department of Internal Medicine, Nagoya University, School of Medicine and Related Hospitals
The Second Department of Internal Medicine, Nagoya University, School of Medicine and Related Hospital
The Second Department of Internal Medicine, Nagoya University, School of Medicine and Related Hospital
The Second Department of Internal Medicine, Nagoya University, School of Medicine and Related Hospital
The Second Department of Internal Medicine, Nagoya University, School of Medicine and Related Hospital
The Second Department of Internal Medicine, Nagoya University, School of Medicine and Related Hospital
The First Department of Internal Medicine, Nagoya City University, School of Medicine
The First Department of Internal Medicine, Nagoya City University, School of Medicine
The First Department of Internal Medicine, Nagoya City University, School of Medicine
The First Department of Internal Medicine, Nagoya City University, School of Medicine
Department of Internal Medicine, Nagoyashi Koseiin Hospital
Department of Internal Medicine, Nagoyashi Koseiin Hospital
Department of Internal Medicine, Nagoyashi Koseiin Hospital
Department of Internal Medicine, Nagoyashi Koseiin Hospital
Department of Internal Medicine, Toyama Prefectural central Hospital
Department of Internal Medicine, Toyama Prefectural central Hospital
Department of Respiratory Disease, Kanazawa Medical College
Department of Respiratory Disease, Kanazawa Medical College
The First Department of Medicine, Chest Disease Research Inistitute, Kyoto University and Related Hospital
The First Department of Medicine, Chest Disease Research Inistitute, Kyoto University and Related Hospital
The First Department of Medicine, Chest Disease Research Inistitute, Kyoto University and Related Hospital
The First Department of Medicine, Chest Disease Research Inistitute, Kyoto University and Related Hospital
The First Department of Medicine, Chest Disease Research Inistitute, Kyoto University and Related Hospital
The First Department of Medicine, Chest Disease Research Inistitute, Kyoto University and Related Hospital
Department of Internal Medicine, Takeda General Hospital
Department of Internal Medicine, Takeda General Hospital
Department of Internal Medicine, Rakusai New Town Hospital, Kansai Medical University
Department of Internal Medicine, Rakusai New Town Hospital, Kansai Medical University
The Second Department of Internal Medicine, Nara Medical College
The Second Department of Internal Medicine, Nara Medical College
The Second Department of Internal Medicine, Nara Medical College
The First Department of Internal Medicine, Kansai Medical University
The First Department of Internal Medicine, Kansai Medical University
The First Department of Internal Medicine, Kansai Medical University
The First Department of Internal Medicine, Kansai Medical University
The First Department of Internal Medicine, Kansai Medical University
Department of Internal Medicine, National Sanatrium Toneyama Hospital and Related Hospitals
Department of Internal Medicine, National Sanatrium Toneyama Hospital and Related Hospitals
Department of Internal Medicine, National Sanatrium Toneyama Hospital and Related Hospitals
Department of Internal Medicine, National Sanatrium Toneyama Hospital and Related Hospitals
Department of Internal Medicine, National Sanatrium Toneyama Hospital and Related Hospitals
Department of Internal Medicine, National Sanatrium Toneyama Hospital and Related Hospitals
Department of Internal Medicine, National Sanatrium Toneyama Hospital and Related Hospitals
Department of Internal Medicine, Wakayama Red Cross Hospital
Department of Internal Medicine, Wakayama Red Cross Hospital
Department of Internal Medicine, Wakayama Red Cross Hospital
Department of Internal Medicine, Wakayama Red Cross Hospital
The Third Department of Internal Medicine, Tokushima University, School of Medicine
Division of Respiratory Disease, Department of Medicine, Kawasaki Medical School
Division of Respiratory Disease, Department of Medicine, Kawasaki Medical School
Division of Respiratory Disease, Department of Medicine, Kawasaki Medical School
Division of Respiratory Disease, Department of Medicine, Kawasaki Medical School
Division of Respiratory Disease, Department of Medicine, Kawasaki Medical School
Department of Internal Medicine, Kure National Hospital
Department of Internal Medicine, Kure National Hospital
Department of Internal Medicine, Kure National Hospital
The First Department of Internal Medicine, Faculty of Medicine and School of Health Sciences, Kyushu University
The First Department of Internal Medicine, Faculty of Medicine and School of Health Sciences, Kyushu University
The First Department of Internal Medicine, Faculty of Medicine and School of Health Sciences, Kyushu University
Research Institute for Disease of the Chest, Faculty of Medicine, Kyushu University
Research Institute for Disease of the Chest, Faculty of Medicine, Kyushu University
The Second Department of Internal Medicine, Fukuoka University, School of Medicine and Related Hospital
The Second Department of Internal Medicine, Fukuoka University, School of Medicine and Related Hospital
The Second Department of Internal Medicine, Fukuoka University, School of Medicine and Related Hospital
The Second Department of Internal Medicine, Nagasaki University, School of Medicine and Related Hospitals
The Second Department of Internal Medicine, Nagasaki University, School of Medicine and Related Hospitals
The Second Department of Internal Medicine, Nagasaki University, School of Medicine and Related Hospitals
The Second Department of Internal Medicine, Nagasaki University, School of Medicine and Related Hospitals
The Second Department of Internal Medicine, Nagasaki University, School of Medicine and Related Hospitals
The Second Department of Internal Medicine, Nagasaki University, School of Medicine and Related Hospitals
The Second Department of Internal Medicine, Nagasaki University, School of Medicine and Related Hospitals
The Second Department of Internal Medicine, Nagasaki University, School of Medicine and Related Hospitals
The Second Department of Internal Medicine, Nagasaki University, School of Medicine and Related Hospitals
The Second Department of Internal Medicine, Nagasaki University, School of Medicine and Related Hospitals
Department of Internal Medicine, Institute for Tropical Medicine, Nagasaki University
Department of Internal Medicine, Institute for Tropical Medicine, Nagasaki University
Department of Internal Medicine, Institute for Tropical Medicine, Nagasaki University
The Second Department of Internal Medicine, Medical College of Oita
The Second Department of Internal Medicine, Medical College of Oita
The Second Department of Internal Medicine, Medical College of Oita
The Second Department of Internal Medicine, Medical College of Oita
The Second Department of Internal Medicine, Medical College of Oita
1987 Volume 61 Issue 8 Pages 914-943
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A well-controlled comparative study was undertaken to assess the clinical efficacy and safety of BRL28500 (BRL), a formulation comprising one part of clavulanic acid and 15 parts of ticarcillin, using piperacillin (PIPC) as a reference drug in patients with respiratory tract infections (RTI).
Patients with apparent clinical signs and symptoms of chronic RTI (chronic bronchitis, diffuse panbronchiolitis, infected bronchiectasis, infected pulmonary emphysema, infected pulmonary fibrosis and infected bronchial asthma), acute exacerbation of chronic RTI, bacterial pneumonia and lung abscess were administered 1.6 g of BRL (1.5 g of ticarcillin plus 0.1 g of clavulanic acid) or 2.0 g of PIPC twice daily by intravenous drip infusion for 14 days in principle.
BRL-treated group and PIPC-treated group were compared in terms of clinical efficacy, improvement of clinical symptoms and signs, bacteriological response, incidence of side effects, abnormal changes in laboratory findings and utility. The following results were obtained:
1. BRL and TIPC were administered to a total of 314 patients (BRL to 161 and PIPC to 153). Clinical efficacy was judged in 269 patients (138 on BRL and 131 on PIPC) excluding 45 patients from total patients by the committee.
Incidence of side effects was evaluated in 293 patients (148 on BRL and 145 on PIPC) and abnormal changes in laboratory findings were asessed in 286 patients (141 on BRL and 145 on PIPC).
2. Clinical efficacy rate for the BRL group and PIPC group was 78.8% and 79.4% in total cases, 82.1% (79 patients) and 79.5% (73 patients) in pneumonia and lung abscess and 74.6% (59 patients) and 79.3% (58 patients) in chronic RTI respectively. There was no statistically significant difference between the two groups.
3. As to improvement of clinical symptoms and signs, improvement of ESR in the BRL group was better than that in the PIPC group on 14th day after administration in patients with pneumonia or lung abscess. On the contrary, improvement of rale, WBC and CRP in the BRL group was inferior to those in the PIPC group on 3rd day after administration in patients with chronic RTI. Significant differences were shown in these items between both groups.
4. Bacteriological response was evaluated in 125 patients (68 on BRL and 57 on PIPC) and eradication of causative organisms was 75.0% for the BRL group and 71.9% for the PIPC group, giving no statistical difference between both groups. However, there was a significant difference in preference for BRL to PIPC in terms of eradication of Klebsiella spp. (87.5% for BRL and 16.7% for PIPC).
When causative organisms were classified into two groups according to susceptibility to PIPC, eradication effect of PIPC (94.7%) was superior (p<0.10) to that of BRL (69.6%) in PIPC-sensitive organisms having 50μg/ml of MIC. On the other hand, in PICP-resistant organisms having 50μg/ml of MIC BRL exerted better eradication effect (66.7%) than PIPC (12.5%) and a significant difference was shown between the two groups.
5. In 293 patients assessed incidence of side effects, five patients treated with BRL and eleven patients treated with PIPC complained of side effects and there was no significant difference between both groups.
6. Abnormal changes in laboratory findings were evaluated in 286 patients. Numbers of patients with the abnormal changes were 45 (31.9%) out of 141 patients treated with BRL and 28 (19.3%) out of 145 patients treated with PIPC respectively and the difference was significant (p<0.05) between both groups. Itemized analysis showed that abnormal changes in GPT were found in 26 (18.6%) out to 140 patients treated with BRL and 14 (10.0%) out of 140 patients treated with PIPC and indicated that elevation of BUN were shown only in the PIPC group (4/127, 3.1%), giving tendency of significant difference (p<0.10) on the above items between the two groups.